Zobrazeno 1 - 10
of 16
pro vyhledávání: '"K., Kaasinen"'
Autor:
Selma K. Kaasinen, Trevor J. Kilpatrick, Melanie Willingham, Ulrich Putz, Jason Howitt, Ian A. Hendry, Simon S. Murray, Junhua Xiao, Agnes W. Wong, Graham L. Barrett
Publikováno v:
The Journal of Neuroscience. 29:4016-4022
Although brain-derived neurotrophic factor (BDNF) has been shown to promote peripheral myelination during development and remyelination after injury, the precise mechanisms mediating this effect remain unknown. Here, we determine that BDNF promotes m
Publikováno v:
International Journal of Developmental Neuroscience. 26:625-634
Nerve cells require trophic signals transmitted from the nerve terminal via the axon in order to survive and develop normally. As the axon may be more than a meter long, specialised mechanisms are needed to transmit these signals. This involves the r
Publikováno v:
Neurochemical Research. 30:703-712
In this study we describe a population of neurons in the adult rat trigeminal ganglion (TG) that express dopamine beta-hydroxylase (DBH) and tyrosine hydroxylase (TH), and transport anti-DBH from their terminals. We have used NGF and NT3 labeled with
Publikováno v:
Pharmacology Biochemistry and Behavior. 78:35-45
The present work addresses the role of polyamines in learning and general behavior by subjecting transgenic mice overexpressing polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT) and their syngenic littermates to neurobehavio
Publikováno v:
Experimental Neurology. 176:203-212
Various isoforms of protein kinase C (PKC), especially the novel PKC subtypes delta, epsilon, and the atypical subtype PKC zeta, are involved in delayed cell death. We studied the expression and late activation of the latter PKC isoforms in compariso
Autor:
Leena Alhonen, Hanna Siiskonen, Selma K. Kaasinen, Mikko I. Kettunen, Juhana M. Hakumäki, Raimo Pussinen, Asla Pitkänen, Karlheinz Kiehne, Karl-Heinz Herzig, Sanna Oikari, Vootele Voikar, Veli-Pekka Korhonen, Juhani Jänne, Markku Penttonen, Tiina Wahlfors
Publikováno v:
Molecular and cellular neurosciences. 34(2)
Diazepam binding inhibitor (DBI) and its processing products are endogenous modulators of GABAA and linked to various brain disorders ranging from anxiety and drug dependence to epilepsy. To investigate the physiological role of endogenously expresse
Publikováno v:
Experimental neurology. 183(2)
Activation of polyamine catabolism in transgenic mice through an overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) results in a massive overaccumulation of the diamine putrescine in most tissues including brain. Putrescine pool in t
Autor:
Leena Alhonen, K. Kaasinen, Tuomo A. Keinänen, Karl-Heinz Herzig, Juhani Jänne, Anne Uimari, Riitta Sinervirta, Tiina-Liisa Räsänen
Publikováno v:
Scandinavian journal of gastroenterology. 38(7)
The male antifertility agent gossypol has been reported to induce spermidine/spermine N1-acetyltransferase (SSAT) in canine prostate cells. As SSAT is the rate-controlling enzyme in the catabolism of the polyamines and is involved in the development
Publikováno v:
The European journal of neuroscience. 12(2)
We recently generated a transgenic mouse line with activated polyamine catabolism through overexpression of spermidine/spermine N1-acetyltransferase (SSAT). A detailed analysis of brain polyamine concentrations indicated that all brain regions of the
Publikováno v:
International Journal of Developmental Neuroscience. 24:569-569