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Autor:
John G. Sled, Elaine Liu, Lisa M. Gazdzinski, Lindsay S. Cahill, Sharon Portnoy, Yu-Qing Zhou, C. David Mazer, Gregory M. T. Hare, Albert K. Y. Tsui, Andrea Kassner
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:994-1005
Cerebral ischemia is a significant source of morbidity in children with sickle cell anemia; however, the mechanism of injury is poorly understood. Increased cerebral blood flow and low hemoglobin levels in children with sickle cell anemia are associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0b8fec54e67168b2821fc492968c1
https://doi.org/10.1177/0271678x16649194
https://doi.org/10.1177/0271678x16649194
Autor:
Rakesh P. Patel, Nikhil Mistry, Tessa Tam, Yevheniy Leshchyshyn, Sanjay Yagnik, Kaho Han, Jaideep Honavar, W. Scott Beattie, Si Yuan Dai, Razak A. Pirani, Philip W. Connelly, C. David Mazer, Tiffanie Kei, Albert K. Y. Tsui, Alexander D. Romaschin, Shelley L. Welker, Gregory M. T. Hare
Publikováno v:
Canadian journal of anaesthesia = Journal canadien d'anesthesie. 65(8)
Hemodilutional anemia is associated with acute kidney injury (AKI) and mortality in patients undergoing cardiac surgery by mechanisms that may include tissue hypoxia. Our hypothesis was to assess if changes in the potential hypoxic biomarkers, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15acf3346f6bdf0cc1b7cebcf929fc3
https://pubmed.ncbi.nlm.nih.gov/29696581
https://pubmed.ncbi.nlm.nih.gov/29696581
Autor:
C. David Mazer, John G. Sled, R. Mark Henkelman, Albert K. Y. Tsui, Neville Chan, Lindsay S. Cahill, Gregory M. T. Hare, Keith M. Lee, Elaine Liu, Philip A. Marsden, Yu-Qing Zhou
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R13-R25
Tissue hypoxia likely contributes to anemia-induced organ injury and mortality. Severe anemia activates hypoxia-inducible factor (HIF) signaling by hypoxic- and neuronal nitric oxide (NO) synthase- (nNOS) dependent mechanisms. However, organ-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250845048d19aa19dbbd5b903bde9056
https://doi.org/10.1152/ajpregu.00411.2013
https://doi.org/10.1152/ajpregu.00411.2013
Publikováno v:
Perfusion. 28:504-511
Introduction: Anemia is an independent predictor of acute kidney injury (AKI) following cardiopulmonary bypass (CPB), possibly due to inadequate renal oxygen delivery. The objective of this study was to investigate the effects of CPB and anemia on ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef85e146e817e37ec59ad649666b7af
https://doi.org/10.1177/0267659113490219
https://doi.org/10.1177/0267659113490219
Autor:
C. David Mazer, Albert K. Y. Tsui, Tina Hu, W. Scott Beattie, Howard Leong-Poi, Andrew J. Baker, Maimoona Muhammad, Elaine Liu, Hiroko Fujii, Gregory M. T. Hare, David F. Wilson
Publikováno v:
Anesthesia & Analgesia. 116:649-662
BACKGROUND Acute β-blockade has been associated with a dose-dependent increase in adverse outcomes, including stroke and mortality. Acute blood loss contributes to the incidence of these adverse events. In an attempt to link the risks of acute blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8066ee02117a66c618b834cf73082fa9
https://doi.org/10.1213/ane.0b013e318280e26d
https://doi.org/10.1213/ane.0b013e318280e26d
Publikováno v:
Environment international. 96
Indoor air pollution is closely related to children's health. Polybrominated diphenyl ethers (PBDEs) and dechlorane plus (DP) transmitted through indoor PM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f07bcafb98663ad11cae58c7e0594e81
https://pubmed.ncbi.nlm.nih.gov/27608428
https://pubmed.ncbi.nlm.nih.gov/27608428
Autor:
Feng Chen, Jeanie K. Y. Tsui, Chun-Ho Liu, Dennis Y.C. Leung, Lilian L.P. Vrijmoed, Wing-Kin Yip
Publikováno v:
Landscape Research. 36:173-188
Vegetation has been well recognized for its ability in improving air quality and alleviating global warming. Tree planting has been used to mitigate urban heat island phenomena, sequester carbon dioxide, and help to trap air pollutants on leaves. Bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a58c28f582ff1abce284f5959cc403a
https://doi.org/10.1080/01426397.2010.547570
https://doi.org/10.1080/01426397.2010.547570
Autor:
Albert K. Y. Tsui, Elaine Liu, Philip A. Marsden, Mostafa H. El-Beheiry, Neil D. Dattani, Hilary P. Grocott, Gregory M. T. Hare, George P. Biro, C. David Mazer
Publikováno v:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 57:779-791
Clinical studies demonstrate that anemia increases the risk of morbidity and mortality. Tissue hypoxia is an attractive but incompletely characterized candidate mechanism of anemia-induced organ injury. Physiological responses that optimize tissue ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2906a86c834f3ee6b528c8565d25318f
https://doi.org/10.1007/s12630-010-9329-x
https://doi.org/10.1007/s12630-010-9329-x
Autor:
Melissa Noronha, Howard Leong-Poi, David F. Wilson, Tenille E Ragoonanan, W. Scott Beattie, Albert K. Y. Tsui, Julie Yu, C. David Mazer, Neil D. Dattani, Elaine Liu, Gordon Tait, Nicholas Mitsakakis, Gregory M. T. Hare
Publikováno v:
Anesthesiology. 111:988-1000
Background Perioperative beta-blockade and anemia are independent predictors of increased stroke and mortality by undefined mechanisms. This study investigated the effect of beta-blockade on cerebral tissue oxygen delivery in an experimental model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b96cb80cfb96334c2540014c2568136
https://doi.org/10.1097/aln.0b013e3181b87f0e
https://doi.org/10.1097/aln.0b013e3181b87f0e