Zobrazeno 1 - 10
of 31
pro vyhledávání: '"K Y, Pak"'
Autor:
Ban-An Khaw, K. Y. Pak, Z. Liu, S. D. Hocherman, Gerald Johnson, Robert D. Okada, D. R. Okada
Publikováno v:
Journal of Nuclear Cardiology. 10:168-176
Technetium-99m glucarate is a myocardial infarct-avid imaging agent. Recent conflicting and inconclusive reports have suggested that the agent may be taken up by ischemic but viable myocardium. The purposes of this study were (1) to determine conclus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b423eaba547c1b27798c8ad7b25e35
https://doi.org/10.1067/mnc.2003.1
https://doi.org/10.1067/mnc.2003.1
Publikováno v:
Journal of Physics B: Atomic, Molecular and Optical Physics. 49:074002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa94f6d5502f8b8b68000382bfdb39db
https://doi.org/10.1088/0953-4075/49/7/074002
https://doi.org/10.1088/0953-4075/49/7/074002
Autor:
E.B. Koenders, Roland A. M. J. Claessens, Frans H.M. Corstens, Otto C. Boerman, J. G. Tibben, K. Y. Pak, Leon F.A.G. Massuger, George F. Borm
Publikováno v:
Nuclear Medicine and Biology. 21:17-24
A new 99m Tc labelling method using a cleavable chelator, RP-1, was developed. In this study Balb/c mice with ovarian carcinoma xenografts received various Fab′ fragments labelled with 99m Tc either directly or via RP-1. Kidney uptake was significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0d8adc36a3704493996e63b4161df3
https://doi.org/10.1016/0969-8051(94)90125-2
https://doi.org/10.1016/0969-8051(94)90125-2
Autor:
G, Mariani, G, Villa, P F, Rossettin, P, Spallarossa, G P, Bezante, C, Brunelli, K Y, Pak, B A, Khaw, H W, Strauss
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(11)
Definitive diagnosis of acute myocardial infarction early in the process is often difficult. An imaging agent that localized quickly and specifically in areas of acute necrosis could provide this critical diagnostic information. To determine whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b882e75a1ca5749f78eb732f6a66c96e
https://pubmed.ncbi.nlm.nih.gov/10565778
https://pubmed.ncbi.nlm.nih.gov/10565778
Publikováno v:
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 4(4)
Similar to other 99mTc-based infarct-avid agents, 99mTc-glucarate localizes in myocardial infarcts. Whether severely ischemic viable myocytes sequester 99mTc-glucarate is uncertain. To assess the infarct specificity, in vitro and in vivo studies were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56abf7a2c064d3ea2e88113abbfd3487
https://pubmed.ncbi.nlm.nih.gov/9278874
https://pubmed.ncbi.nlm.nih.gov/9278874
Autor:
Ban-An Khaw, D Bacciardi, L. Bodei, N Molea, Romano Bianchi, J. Narula, H. W. Strauss, E Lazzeri, Giuliano Mariani, K. Y. Pak, L. DiLuca
Publikováno v:
Radioactive Isotopes in Clinical Medicine and Research ISBN: 9783034877749
99mTc-D-Glucaric acid (99mTcGLA) favourably accumulates in animal models of acute ischemia/early myocardial necrosis and in human tumor xenografts. This study evaluated the biodistribution pharmacokinetics and radiation dosimetry (using the MIRD appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55715ac05d506b4970e9e7c1971448dd
https://doi.org/10.1007/978-3-0348-7772-5_54
https://doi.org/10.1007/978-3-0348-7772-5_54
Autor:
Margreet Jonker, G. Treacy, K. Y. Pak, A. F. Lobuglio, J. Iuliucci, S.H. Tam, E. Wilson, K. Bakker, P. van Eerd, W. Slingerland, P. E. Daddona, G. Riethmüller, Peter Rieber
Publikováno v:
Clinical and experimental immunology. 93(3)
SUMMARY Chimeric M-T412 (cM-T412). an anti-CD4 antibody, was tolerated in chimpanzees at a dosage of 5 mg/kg per day for up to 7 consecutive days, or 5 mg/kg per dose, twice weekly for 4 weeks. All cM-T412-treated chimpanzees showed a prolonged CD4 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5020e7857f67bfc81adb3fcb0dd3ec8
https://pubmed.ncbi.nlm.nih.gov/8103714
https://pubmed.ncbi.nlm.nih.gov/8103714
Autor:
K. Y. Pak, Leon F.A.G. Massuger, P. Kenemans, S. P. Strijk, Roland A. M. J. Claessens, F.H.M. Corstens, J. G. Tibben, C. P. T. Schijf
Publikováno v:
Nuclear medicine communications. 13(12)
Fab' fragments of the monoclonal antibody OV-TL 3, that recognizes an ovarian carcinoma-associated antigen (OA3), were labelled with 99Tcm using D-glucarate as a ligand. Twenty patients suspected of having primary or recurrent ovarian cancer received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1505c1488c7cefea7018f941e3a934bf
https://pubmed.ncbi.nlm.nih.gov/1465272
https://pubmed.ncbi.nlm.nih.gov/1465272
Autor:
J E, Looney, D M, Knight, M, Arevalo-Moore, H, Trinh, K Y, Pak, M R, Dalesandro, E P, Rieber, G, Riethmuller, P E, Daddona, J, Ghrayeb
Publikováno v:
Human antibodies and hybridomas. 3(4)
The use of murine anti-CD4 monoclonal antibodies (MAbs) has shown considerable promise for the treatment of allograft rejection and rheumatoid arthritis. We have constructed mouse-human anti-CD4 antibodies with the goal of increasing their clinical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4fd11ab40b43caed2034c6f467d65dd
https://pubmed.ncbi.nlm.nih.gov/1477300
https://pubmed.ncbi.nlm.nih.gov/1477300
Autor:
K Y, Pak, M A, Nedelman, M, Kanke, B A, Khaw, J A, Mattis, H W, Strauss, R T, Dean, H J, Berger
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 33(1)
An instant kit method for labeling antibody Fab' fragments was developed. The method utilizes a ligand exchange reaction between the intermediate complex 99mTc-D-glucarate and the free sulfhydryl groups on the antibody Fab' fragment. Radiolabeling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c79b223c3d7cef78711467107e73d6d
https://pubmed.ncbi.nlm.nih.gov/1730981
https://pubmed.ncbi.nlm.nih.gov/1730981