Zobrazeno 1 - 10
of 260
pro vyhledávání: '"K Y, Fu"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/3873584e6d00486f996ec999445c17c3
Autor:
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Qihao Guo, Kin Y. Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-20 (2023)
Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.
Externí odkaz:
https://doaj.org/article/1179b0a6657942b580123646d3f1699e
Autor:
Jong‐Chan Park, Natalia Barahona‐Torres, So‐Yeong Jang, Kin Y. Mok, Haeng Jun Kim, Sun‐Ho Han, Kwang‐Hyun Cho, Xiaopu Zhou, Amy K. Y. Fu, Nancy Y. Ip, Jieun Seo, Murim Choi, Hyobin Jeong, Daehee Hwang, Dong Young Lee, Min Soo Byun, Dahyun Yi, Jong Won Han, Inhee Mook‐Jung, John Hardy
Publikováno v:
Advanced Science, Vol 9, Iss 23, Pp n/a-n/a (2022)
Abstract Recent multi‐omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite the possibility of biological subtypes within these patients.
Externí odkaz:
https://doaj.org/article/34ef263cdb004c159da392487b587d25
Autor:
Tao Ye, Yangyang Duan, Hayley W. S. Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Ye et al demonstrate a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases. As proof-of-concept they apply this method to examining amyloid precursor protein gene dosage effects in an
Externí odkaz:
https://doaj.org/article/70fb7c21e42e47428a1ea40e2a8b140e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no disease-modifying treatment. AD progression is characterized by cognitive decline, neuroinflammation, and accumulation of amyloid-beta (Aβ) and neurofibrillary t
Externí odkaz:
https://doaj.org/article/5e145d10ba444c13a408a1dd72b67715
Autor:
Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that
Externí odkaz:
https://doaj.org/article/daea0c2091424966946bd2ca4738d8a4
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The high prevalence of Alzheimer’s disease (AD) among the elderly population and its lack of effective treatments make this disease a critical threat to human health. Recent epidemiological and genetics studies have revealed the polygenic nature of
Externí odkaz:
https://doaj.org/article/49529fe61adf44eb80ba224f1f28c0ff
Autor:
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Nicole C. H. Lai, Yolanda Y. T. Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Kit Cheung, Estella P. S. Tong, Ho Ko, Maryam Shoai, Kin Y. Mok, John Hardy, Vincent C. T. Mok, Timothy C. Y. Kwok, Amy K. Y. Fu, Nancy Y. Ip
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Dozens of Alzheimer's disease (AD)‐associated loci have been identified in European‐descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population. Methods TaqMan array genot
Externí odkaz:
https://doaj.org/article/79ab601c621849de94302d253f43db99
Autor:
Shuo Gu, Wing-Yu Fu, Amy K. Y. Fu, Estella Pui Sze Tong, Fanny C. F. Ip, Xuhui Huang, Nancy Y. Ip
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract The receptor tyrosine kinase, erythropoietin-producing hepatocellular A4 (EphA4), was recently identified as a molecular target for Alzheimer’s disease (AD). We found that blockade of the interaction of the receptor and its ligands, ephrin
Externí odkaz:
https://doaj.org/article/685192b840f44ae194276059f135d92a
Autor:
Zhongzhen Wu, Liangliang Liu, Shunning Li, Shunping Ji, Pinghu Chen, Suihan Cui, Zhengyong Ma, Yuchang Weng, Qian Huang, Zhongcan Wu, Hao Wu, Yuan Lin, Ricky K. Y. Fu, Hai Lin, Xiubo Tian, Paul K. Chu, Feng Pan
Publikováno v:
Research, Vol 2019 (2019)
Hydrophobic/superhydrophobic materials with intrinsic water repellence are highly desirable in engineering fields including anti-icing in aerocrafts, antidrag and anticorrosion in ships, and antifog and self-cleaning in optical lenses, screen, mirror
Externí odkaz:
https://doaj.org/article/5d56e92c04194c05bdb8c957f334e0ae