Výsledky vyhledávání

c-erbB-2 Antisense Oligonucleotides Inhibit Serum-Induced Cell Spreading of Ovarian Cancer Cells

Autor: K, Wiechen

Publikováno v: Methods in molecular medicine. 39

Amplification or overexpression of the c-erbB-2 oncogene (also known as HER-2, neu) is a frequent event in many types of human cancer including 20-30% of ovarian cancers where it characterizes a group of patients with poor prognosis (1,2). The expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43b41a2f537740ba404289b3fe3e2b69
https://pubmed.ncbi.nlm.nih.gov/21340838

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Involvement of the c-erbB-2 oncogene product in the EGF-induced cell motility of SK-OV-3 ovarian cancer cells

Autor: K, Wiechen, S, Karaaslan, M, Dietel

Publikováno v: International journal of cancer. 83(3)

The epidermal growth factor (EGF) induces the rapid formation of dendritic processes and the dissociation of SK-OV-3 ovarian cancer cells. The SK-OV-3 cell line is characterized by over-expression of the c-erbB-2 oncogene product (p185(c-erbB-2)). To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3decad9de3c9de7279d22ab559340e43
https://pubmed.ncbi.nlm.nih.gov/10495435

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Antisense phosphorothioate oligodeoxynucleotide down-regulation of the insulin-like growth factor I receptor in ovarian cancer cells

Autor: M, Müller, M, Dietel, A, Turzynski, K, Wiechen

Publikováno v: International journal of cancer. 77(4)

The insulin-like growth factors (IGF-I and IGF-II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the IGF-I receptor has been demonstrated in a variety of human tumor cell lines including ovar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9cebb7a2124e2099ed5fcd31b5a2bfc
https://pubmed.ncbi.nlm.nih.gov/9679760

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Selection of a high activity c-erbB-2 ribozyme using a fusion gene of c-erbB-2 and the enhanced green fluorescent protein

Autor: K, Wiechen, C, Zimmer, M, Dietel

Publikováno v: Cancer gene therapy. 5(1)

In different types of human cancer there is an overexpression of the c-erbB-2 (HER2/neu) oncogene, which is thought to be involved in tumor progression. Therefore the c-erbB-2 oncogene is an attractive target for tumor-specific gene therapy. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a23bc301626d03d5f10b23f4337bbb0a
https://pubmed.ncbi.nlm.nih.gov/9476966

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Two distinct functional effects of protein phosphatase inhibitors on guinea-pig cardiac L-type Ca2+ channels

Autor: K Wiechen, D T Yue, Stefan Herzig

Publikováno v: The Journal of physiology. 484

1. The effects of the phosphatase inhibitors okadaic acid and calyculin A on single guinea-pig ventricular L-type Ca2+ channels were studied. The inactive derivative norokadaone was used as a negative control. 2. The two known effects of cAMP-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654cf767e33d775730fe0508bc99da28
https://pubmed.ncbi.nlm.nih.gov/7623278

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Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor

Autor: J, Neumann, P, Bokník, S, Herzig, W, Schmitz, H, Scholz, K, Wiechen, N, Zimmermann

Publikováno v: The Journal of pharmacology and experimental therapeutics. 271(1)

Calyculin A (CyA; 1 microM) increased the force of contraction in isolated guinea pig papillary muscles to 144% of control without affecting contraction parameters. The effect of CyA on L-type calcium channels was assessed in cell-attached patches of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21b1b37c0029e994dbc0231adedb9a55
https://pubmed.ncbi.nlm.nih.gov/7965753

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