Zobrazeno 1 - 10
of 13
pro vyhledávání: '"K W Barbour"'
Publikováno v:
Molecular Biology and Evolution. 15:312-325
Transcription of the murine D7Rp2e gene is highly variable among species of the genus Mus, indicating that extensive modifications in the gene's regulatory elements have occurred during evolution. Since promoter regions are well known to harbor cis-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ccaced6c8459ffe31c6919c6c7b465
https://doi.org/10.1093/oxfordjournals.molbev.a025928
https://doi.org/10.1093/oxfordjournals.molbev.a025928
Publikováno v:
Pediatric surgery international. 20(5)
The use of ureteric stents in reimplantation surgery is important. The younger the patient, the more important the stenting of ureters post reimplantation becomes, because even minimal oedema following surgery will produce ureteric obstruction unless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d016e6b42309b39464a3d8e20a6132
https://pubmed.ncbi.nlm.nih.gov/15175890
https://pubmed.ncbi.nlm.nih.gov/15175890
Publikováno v:
Molecular pharmacology. 48(1)
Thymidylate synthase (TS) is a homodimeric enzyme that catalyzes the reductive methylation of dUMP by N5,N10-methylene-5,6,7,8-tetrahydrofolic acid, to form dTMP. Inhibition of TS by the dUMP analog 5-fluoro-dUMP (FdUMP) occurs through the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8776ec64829cf640ff9cd7f2237ba94a
https://pubmed.ncbi.nlm.nih.gov/7623777
https://pubmed.ncbi.nlm.nih.gov/7623777
Publikováno v:
Molecular pharmacology. 44(2)
A major mechanism underlying the cytotoxicity of fluoropyrimidine analogs such as 5-fluorouracil and 5-fluoro-2'-deoxyuridine (FdUrd) occurs via the formation of 5-fluoro-2'-deoxyuridylate (FdUMP), a tight-binding inhibitor of thymidylate synthase (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::111e11c084d4be6a974e7321480c053e
https://pubmed.ncbi.nlm.nih.gov/8355668
https://pubmed.ncbi.nlm.nih.gov/8355668
Publikováno v:
Advances in experimental medicine and biology. 339
The human colorectal tumor cell line HCT 116 was resident to the cytotoxic effects of 5-fluorodeoxyuridine (FdUrd). The response to FdUrd was increased only slightly by the presence of 10 microM folinic acid (CF). HCT 116 formed FdUMP and CH2H4PteGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93f11b813ffa5cc493db8fd07eab2b3d
https://pubmed.ncbi.nlm.nih.gov/8178730
https://pubmed.ncbi.nlm.nih.gov/8178730
Publikováno v:
Molecular pharmacology. 42(2)
Structural changes in the macromolecular targets of pharmacological agents can result in alterations in the efficacy of these agents. In previous studies, we identified a variant structural form of thymidylate synthase (TS) that is associated with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e8656bfc08e75f09944bd49a9049adb2
https://pubmed.ncbi.nlm.nih.gov/1355260
https://pubmed.ncbi.nlm.nih.gov/1355260
Publikováno v:
Molecular Biology and Evolution.
The RP2 gene is one of several genes that are regulated by androgens in the mouse kidney. Previous studies have demonstrated that androgen inducibility of RP2 transcription varies among species within the genus Mus, indicating extensive evolutionary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74d33a7c0fd034983e34870bd40271a
https://doi.org/10.1093/oxfordjournals.molbev.a040675
https://doi.org/10.1093/oxfordjournals.molbev.a040675
Publikováno v:
Molecular pharmacology. 37(4)
Previously, we identified an altered structural form of thymidylate synthase (TS) in a human colonic tumor cell line. This form, which is encoded by a variant structural gene, renders cells relatively resistant to 5-fluoro-2'-deoxyuridine as a result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7402e7a588cb8c0d52627a077543b8b
https://pubmed.ncbi.nlm.nih.gov/2325636
https://pubmed.ncbi.nlm.nih.gov/2325636
Publikováno v:
Molecular and Cellular Biology. 9:477-483
Androgen control of the RP2 gene in the mouse kidney has been modified during evolution. In inbred mice (Mus domesticus), the concentrations of mRNAs encoded by RP2 undergo a 10- to 12-fold induction in response to testosterone; in other Mus species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f973d5cab5480aebdda453c0d3a0b7a3
https://doi.org/10.1128/mcb.9.2.477
https://doi.org/10.1128/mcb.9.2.477
Publikováno v:
Molecular pharmacology. 34(4)
Inhibition of thymidylate synthase (TS) is an important mechanism of action of fluoropyrimidine antimetabolites. Thus, TS structure and expression are expected to be determinants of response to these agents. The role of TS in fluoropyrimidine respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f69702b726664fc3302f5f4733053db
https://pubmed.ncbi.nlm.nih.gov/2971872
https://pubmed.ncbi.nlm.nih.gov/2971872