Zobrazeno 1 - 9
of 9
pro vyhledávání: '"K W, Scotto"'
Autor:
K W, Scotto, R A, Johnson
Publikováno v:
Molecular interventions. 1(2)
Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor cells, resulting in the development of multidrug resistance (MDR). Not surpri
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)
Ecteinascidin 743 (ET-743) is a potent antitumor agent from the Caribbean tunicate Ecteinascidin turbinata and is presently in clinical trials for human cancers. To better understand how ET-743 might be used clinically, the present study used SRB ass
Publikováno v:
The Journal of biological chemistry. 275(4)
The MDR1 promoter is subject to control by various internal and external stimuli. We have previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by the histone deacetylase inhibitors, trichostatin A and sodium butyrate, t
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)
Overexpression of P-glycoprotein (Pgp), a multidrug transporter encoded by the MDR1 gene, is associated with chemoresistance in some human solid tumor malignancies. To date, analyses of MDR1 levels in solid tumors have examined constitutive increases
Autor:
T A, Ince, K W, Scotto
Publikováno v:
Cancer research. 56(9)
Cellular resistance to multiple chemotherapeutic agents is most often due to the overexpression of P-glycoprotein (Pgp). The mechanisms(s) underlying Pgp overexpression had not been determined, due, in part, to a failure to reproduce the overexpressi
Publikováno v:
Advances in experimental medicine and biology. 338
Publikováno v:
Molecular and Cellular Biology. 4:38-48
Nucleotide sequence analysis of two cDNA clones, one shown to direct the synthesis in Escherichia coli of the pI 6.7 form of the 20,000-molecular-weight class of Chinese hamster lung cell dihydrofolate reductase, and the other shown to direct the syn
Publikováno v:
Cancer research. 48(11)
Six independently derived multidrug-resistant Chinese hamster cell lines selected with vincristine, daunorubicin, actinomycin D, or colchicine were probed by in situ hybridization techniques with the cloned cDNA, p5L-18, to chromosomally localize kno
Publikováno v:
Progress in clinical and biological research. 175