X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA

Autor: P J Bond, R Langridge, Stephen J. Lippard, K. W. Jennette

Publikováno v: Proceedings of the National Academy of Sciences. 72:4825-4829

Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad35dc688a844dc1c2b88d21e9fba52
https://doi.org/10.1073/pnas.72.12.4825

Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids

Autor: I. B. Weinstein, K. W. Jennette, Alan M. Jeffrey, F. A. Beland, S. H. Blobstein, Ronald G. Harvey

Publikováno v: Biochemistry. 16:932-938

The covalent binding of benzo[a]pyrene 4,5-oxide and benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide isomer I and isomer II to nucleic acids in aqueous acetone solution has been investigated. Benzo[a]pyrene 4,5-oxide reacted preferentially with guanosine r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318d1ba5092d5764c50938f16387a2f0
https://doi.org/10.1021/bi00624a019

Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants

Autor: Alan M. Jeffrey, Ronald G. Harvey, Curtis C. Harris, Koji Nakanishi, K. Grzeskowiak, Herman Autrup, I. B. Weinstein, K. W. Jennette

Publikováno v: Jeffrey, A M, Weinstein, I B, Jenette, K W, Grzeskowiak, K, Nakanishi, K, Harvey, R G, Autrup, H & Harris, C 1977, ' Structures of benzo(a)pyrene-nucleic acid adducts formed in human and bovine bronchial explants ', Nature, vol. 269, no. 5626, pp. 348-350 . https://doi.org/10.1038/269348a0

PUBLICATION by Sims et al. of evidence that the 7,8-dihydrodiol-9,10-oxide of benzo(a)pyrene (BP) is a metabolic intermediate in the covalent binding of this ubiquitous polycyclic aromatic hydrocarbon to DNA in hamster embryo cells1 was followed by m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0e94f43085f811c4f77d8bbb53af51
https://doi.org/10.1038/269348a0

ChemInform Abstract: ABSOLUTE CONFIGURATION OF A RIBONUCLEIC ACID ADDUCT FORMED IN VIVO BY METABOLISM OF BENZO(A)PYRENE

Autor: Alan M. Jeffrey, K. W. Jennette, Koji Nakanishi, H. Cho, Ronald G. Harvey, I. B. Weinstein, Hiroshi Kasai

Publikováno v: Chemischer Informationsdienst. 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ffececb357c8c64f6a8c04a8e3ef29c
https://doi.org/10.1002/chin.197714059

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo

Autor: Chris Harris, Koji Nakanishi, Alan M. Jeffrey, S. H. Blobstein, Ronald G. Harvey, I. B. Weinstein, Hiroshi Kasai, K. W. Jennette, Herman Autrup

Publikováno v: Science (New York, N.Y.). 193(4253)

Evidence has been obtained that a specific isomer of a diol epoxide derivative of benzo(a)pyrene, (+/-)-7 beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, is an intermediate in the binding of benzo(a)pyrene to RNA in cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8684e38d4041139739f25108d6c27a1f
https://pubmed.ncbi.nlm.nih.gov/959820