Zobrazeno 1 - 10
of 18
pro vyhledávání: '"K W, Bair"'
Autor:
Z, Thale, F R, Kinder, K W, Bair, J, Bontempo, A M, Czuchta, R W, Versace, P E, Phillips, M L, Sanders, S, Wattanasin, P, Crews
Publikováno v:
The Journal of organic chemistry. 66(5)
The structural chemistry and biological activity of the bengamide class of compounds have been further characterized. Extracts prepared from recollected Jaspis cf. coriacea from five sites in Fiji were pooled. Six new bengamides, M (7b), N (8a), O (8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8b3a2aef31a90da02170d9c802d4ebe
https://pubmed.ncbi.nlm.nih.gov/11262120
https://pubmed.ncbi.nlm.nih.gov/11262120
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 53(5)
The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9331104357e6bd0634cdb843221569f
https://pubmed.ncbi.nlm.nih.gov/10424344
https://pubmed.ncbi.nlm.nih.gov/10424344
Autor:
P, Ettmayer, D, France, J, Gounarides, M, Jarosinski, M S, Martin, J M, Rondeau, M, Sabio, S, Topiol, B, Weidmann, M, Zurini, K W, Bair
Publikováno v:
Journal of medicinal chemistry. 42(6)
Following earlier work on cystine-bridged peptides, cyclic phosphopeptides containing nonreducible mimics of cystine were synthesized that show high affinity and specificity toward the Src homology (SH2) domain of the growth factor receptor-binding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0051925f0b358205bc55d8021a469321
https://pubmed.ncbi.nlm.nih.gov/10090780
https://pubmed.ncbi.nlm.nih.gov/10090780
Publikováno v:
Anti-cancer drug design. 13(7)
A mechanism of action study was performed with 14 novel DNA binding agents characterized structurally as 2-(arylmethylamino)-1,3-propanediols (AMAPs). Correlations between 8226 myeloma cell colony formation and DNA damage were performed using soft ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b75357f8c4e37b7790f40de0449332de
https://pubmed.ncbi.nlm.nih.gov/9807165
https://pubmed.ncbi.nlm.nih.gov/9807165
Publikováno v:
Anticancer research. 17(1A)
Multidrug resistance (MDR) is a major impediment to the effective treatment of cancer. We have used multicellular tumor spheroids (MTS) as a model to investigate whether MDR can be reversed in a three dimensional structure. MTS are tightly associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc03bb9e18a464bb6314c07d40ef3738
https://pubmed.ncbi.nlm.nih.gov/9066642
https://pubmed.ncbi.nlm.nih.gov/9066642
Autor:
A, Archinal-Mattheis, R W, Rzepka, T, Watanabe, N, Kokubu, Y, Itoh, N J, Combates, K W, Bair, D, Cohen
Publikováno v:
Oncology research. 7(12)
Multidrug resistance (MDR) is considered to be an important impediment to the effective treatment of cancer. P-glycoprotein, the drug efflux pump that mediates this resistance, can be inhibited by a wide variety of pharmacological agents, resulting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70514cf9fd780680f0b39858da82c526
https://pubmed.ncbi.nlm.nih.gov/8704277
https://pubmed.ncbi.nlm.nih.gov/8704277
Publikováno v:
Biochemical pharmacology. 42(11)
Following recovery from a 4-hr exposure to clinically achievable concentrations of the topoisomerase II inhibitors Adriamycin, teniposide, or amsacrine or the putative topoisomerase II inhibitor crisnatol, murine erythroleukemic cells remained viable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be67a7d9ac74dfbf8e8a6e6db7f3459e
https://pubmed.ncbi.nlm.nih.gov/1659821
https://pubmed.ncbi.nlm.nih.gov/1659821
Autor:
D D, Von Hoff, J G, Kuhn, K A, Havlin, A M, Langevin, T D, Brown, G R, Weiss, J N, Turner, J, Purvis, V S, Lucas, K W, Bair
Publikováno v:
Cancer research. 50(23)
502U83 is an arylmethylaminopropanediol derivative exhibiting significant antineoplastic activity in a number of murine and human tumor models. In this Phase I trial, a 1-h or 4-h infusion of the agent was administered i.v. in 250 ml of 5% dextrose i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c6ffb42eed132f0ddd47c16d3a4043a
https://pubmed.ncbi.nlm.nih.gov/2253197
https://pubmed.ncbi.nlm.nih.gov/2253197
Publikováno v:
Raman and Luminescence Spectroscopies in Technology II.
The binding of two isomeric 2-[(chysenylmethyl)amino]-2-methyl- 1 ,3-propanediols (AMAPs) to the biopolymer poly(dG-dC)"poly(dG-dC) was studied using Raman spectroscopy. The Raman spectra of the bound AMAPs were obtained by subtracting the Raman spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f0ac67b7a9fc10ebdad857c762e347e
https://doi.org/10.1117/12.22912
https://doi.org/10.1117/12.22912
Publikováno v:
Cancer research. 50(12)
The pharmacodynamics of a new series of antitumor DNA intercalators, known as arylmethylaminopropanediols (AMAPs), has been evaluated in vitro against adherent (MCF-7 human breast cancer) and nonadherent (P388 murine leukemia) cell lines. Previous wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad552dd1e19c8897afeafe4aa9dfa16
https://pubmed.ncbi.nlm.nih.gov/2340515
https://pubmed.ncbi.nlm.nih.gov/2340515