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Abstract P6-09-12: Breast cancer characteristics and the levonorgestrel intrauterine device. A monocentric retrospective study

Autor: Patrick Berteloot, H. Wildiers, Patrick Neven, Ignace Vergote, A Smeets, E. Van Limbergen, Annouschka Laenen, Karin Leunen, Caroline Weltens, Frédéric Amant, E Borowski, A Poppe, C Remmerie, Stéphanie Peeters, M-R Christiaens, Ines Nevelsteen, W Poppe, K. Van Asten, Guiseppe Floris

Publikováno v: Cancer Research. 76:P6-09

OBJECTIVE: The levonorgestrel-intrauterine device (LNG-IUD) is a widely used contraceptive method. It is not clear if LNG-IUD users are more likely to develop breast cancer. Breast cancer growth through the estrogen and/or the human epidermal growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d25eb101b5e1aa2b1c05be33641807d
https://doi.org/10.1158/1538-7445.sabcs15-p6-09-12

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Abstract P5-08-31: Withdrawal of exogenous hormones affects prognostic multigene signature results in early luminal breast cancer

Autor: K. Van Asten, Guiseppe Floris, Annouschka Laenen, P De Vries, Anneleen Lintermans, Patrick Neven, Lynn Jongen, H. Wildiers

Publikováno v: Cancer Research. 76:P5-08

Background Early breast cancer (BC) outcomes are mainly estimated based on clinicopathological parameters and rarely include proliferation markers: (Ki-67), and multigene signatures (MGS), which are typically measured in tumors from resection specime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad87e0bc53e779d7574b5970b2544085
https://doi.org/10.1158/1538-7445.sabcs15-p5-08-31

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Body mass index, age at breast cancer diagnosis, and breast cancer subtype: a cross-sectional study

Autor: Annouschka Laenen, I. Nevelstreen, Ann Smeets, Philippe Moerman, Robert Paridaens, Olivier Brouckaert, Caroline Weltens, E. Van Limbergen, Giuseppe Floris, Patrick Neven, A. Soubry, Ignace Vergote, Hans Wildiers, K. Van Asten

Publikováno v: Breast cancer research and treatment. 168(1)

Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e628ea2b7fb6b8fcdaf70eaa8b012b4
https://pubmed.ncbi.nlm.nih.gov/29159760

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Abstract P1-13-08: Arthralgia and changes in serum levels of IGF-I, its binding protein and estrogen in breast cancer patients on endocrine agents

Autor: Karin Leunen, Frédéric Amant, K. Van Asten, Johan Verhaeghe, Anneleen Lintermans, Dirk Vanderschueren, Pieter Vermeersch, A Smeets, Patrick Neven, H. Wildiers, Robert Paridaens, M-R Christiaens

Publikováno v: Cancer Research. 73:P1-13

Objective Aromatase inhibitors (AIs) frequently induce or enhance musculoskeletal problems, also known as the AI-induced musculoskeletal syndrome (AIMSS). Underlying mechanisms are unknown, likely multiple and induced by low estrogen levels. We hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eeb7dccdd31c1a23b79f2c020023e93
https://doi.org/10.1158/0008-5472.sabcs13-p1-13-08

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Abstract P1-13-09: Sensitive liquid chromatography-tandem mass spectrometry method for serum estradiol and estrone assessment without derivatisation, overcoming cross reactivity with exemestane

Autor: Ivo Jans, Dirk Vanderschueren, Jaak Billen, K. Van Asten, Anneleen Lintermans, Patrick Neven, Pieter Vermeersch, Steven Pauwels

Publikováno v: Cancer Research. 73:P1-13

Objective Measuring serum estrogen levels in postmenopausal women on oral aromatase inhibitors is important but challenging. Direct immunoassays are the most widely used techniques for measuring serum estradiol (E2) in research and clinical laborator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb1850e765b129bccbf8a6f99bdc085d
https://doi.org/10.1158/0008-5472.sabcs13-p1-13-09

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Genetic variant in the osteoprotegerin gene is associated with aromatase inhibitor-related musculoskeletal toxicity in breast cancer patients

Autor: Patrick Neven, T. Van Brussel, K. Van Asten, Diether Lambrechts, Dirk Vanderschueren, Lynn Jongen, Johan Verhaeghe, Anneleen Lintermans, Annouschka Laenen

Publikováno v: European journal of cancer (Oxford, England : 1990). 56

Background Aromatase inhibitor (AI) therapy is associated with musculoskeletal (MS) toxicity, which adversely affects quality of life and therapy adherence. Our objective was to evaluate whether genetic variants may predict endocrine therapy-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1555974597aeeb4b11915cad8d71cd4f
https://pubmed.ncbi.nlm.nih.gov/26798969

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A prospective assessment of musculoskeletal toxicity and loss of grip strength in breast cancer patients receiving adjuvant aromatase inhibitors and tamoxifen, and relation with BMI

Autor: Ann Smeets, M-R Christiaens, Dirk Vanderschueren, Caroline Weltens, Annouschka Laenen, Robert Paridaens, Anneleen Lintermans, E. Van Limbergen, Patrick Neven, Hans Wildiers, K. Van Asten, Johan Verhaeghe, Karin Leunen

Publikováno v: Breast cancer research and treatment. 146(1)

Aromatase inhibitor (AI) therapy for estrogen receptor-positive breast cancer is known to induce or enhance musculoskeletal problems. We have previously reported that loss of grip strength is more pronounced in AI-users with extremes in BMI. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388fa0ec8624fb722197892199a69cdf
https://pubmed.ncbi.nlm.nih.gov/24816806

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Withdrawal of hormone replacement therapy might affect multigene signature results in early luminal breast cancer

Autor: Hans Wildiers, Lynn Jongen, Patrick Berteloot, Giuseppe Floris, K. Van Asten, Patrick Neven

Publikováno v: Annals of Oncology. 26:437-438

In this case-report we established a discordance of luminal subtype between core needle biopsy results at breast cancer diagnosis and surgical specimen results after hormone replacement therapy withdrawal at diagnosis. This observation might suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5f15cc828d6faba51a9e94bda4b07c
https://doi.org/10.1093/annonc/mdu532

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