Zobrazeno 1 - 10
of 38
pro vyhledávání: '"K V Thrivikraman"'
Publikováno v:
Neuroendocrinology
Introduction: Activation of the locus coeruleus-noradrenergic (LC-NA) system during awakening is associated with an increase in plasma corticosterone and cardiovascular tone. These studies evaluate the role of the LC in this corticosterone and cardio
Publikováno v:
Psychoneuroendocrinology. 38:1067-1077
Summary Background The vagus nerve is important in maintaining HPA axis and sympatho-adrenal system (SAS) homeostasis, however little is known about the effect of vagus nerve stimulation (VNS), as used therapeutically, on these functions. Accordingly
Publikováno v:
Neuropharmacology. 60:1135-1141
Corticotropin-releasing factor (CRF) functions as one of the major mediators of the mammalian stress response and appears to play a key role in the pathophysiology of mood and anxiety disorders. Small molecule CRF₁ receptor antagonists may represen
Publikováno v:
Psychopharmacology. 192:385-396
Corticotropin-releasing factor (CRF) is the primary physiologic regulator of the hypothalamic-pituitary-adrenal (HPA) axis and serves to globally coordinate the mammalian stress response. Hyperactivity of central nervous system CRF neurotransmission,
Publikováno v:
Psychoneuroendocrinology. 31:553-564
Experimental environmental enrichment (EE) is usually applied in adulthood or immediately after weaning, with robust effects on physiology and behaviour. To investigate the effects of EE earlier in life, female rats were maintained under moderate enr
Publikováno v:
Journal of Endocrinology. 186:R7-R12
This study investigated the effects of acute and chronic restraint stress during the third week of pregnancy on placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) activity in rats. Acute exposure to stress on gestational day 20 immedi
Publikováno v:
Psychoneuroendocrinology. 30:520-533
Summary Burgeoning evidence supports a preeminent role for early- and late-life stressors in the development of physio- and psychopathology. Handling-maternal separation (HMS) in neonatal Long Evans hooded rats leads to stable phenotypes ranging from
Autor:
Shakti Sharma, Michael J. Meaney, Christian Caldji, Charles B. Nemeroff, K. V. Thrivikraman, Paul M. Plotsky
Publikováno v:
Neuropsychopharmacology. 30:2192-2204
In a series of studies on the long-term consequences of neonatal rearing, we compared hypothalamic and extrahypothalamic central corticotropin-releasing factor (CRF) systems in male rats reared under conditions of animal facility rearing, nonhandling
Publikováno v:
Biological Psychiatry. 55:367-375
Maternally separated rats exhibit exaggerated hypothalamic-pituitary-adrenal responses to an acute stressor but normal diurnal trough functioning. We hypothesized that maternally separated rats experience adequate proactive glucocorticoid negative fe
Publikováno v:
Psychoneuroendocrinology. 29:279-289
Neonatal maternal separation of rat pups has been shown to produce long-term increases in hypothalamic-pituitary-adrenal (HPA) axis responsiveness, elevated levels of hypothalamic corticotropin releasing factor (CRF) mRNA in the hypothalamic paravent