Zobrazeno 1 - 10 of 108 pro vyhledávání: '"K V, Derkach"'
1
Akademický článek
Influence of metformin therapy and treatment with an allosteric luteinizing hormone agonist and chorionic gonadotropin on spermatogenesis in male rats with obesity
Autor: K. V. Derkach, I. Yu. Morina, L. V. Bayunova, A. A. Bakhtuykov, E. A. Didenko, V. N. Sorokoumov, I. V. Romanova, A. O. Shpakov
Publikováno v: Ожирение и метаболизм, Vol 20, Iss 3, Pp 217-226 (2023)
BACKGROUND: In men, obesity is accompanied by a complex of metabolic and hormonal disorders, which leads to androgen deficiency and impaired spermatogenesis. Antidiabetic drugs, including metformin (MF), and luteinizing hormone receptor (LHR) agonist
Externí odkaz: https://doaj.org/article/4a0244e4053045088cf961accc79a4c8
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2
Akademický článek
The Role of Apelin in the Functioning of the Reproductive System
Autor: A. O. Shpakov, K. V. Derkach
Publikováno v: Acta Biomedica Scientifica, Vol 4, Iss 3, Pp 7-17 (2019)
Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism. In the recent years, the evidence has been obtained that all
Externí odkaz: https://doaj.org/article/48782c95e3414e73a084c243b8332b67
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3
Akademický článek
Content of anthocyans in sweet corn with different grain coloring
Autor: A. O. Psolova, K. V. Derkach, T. M. Satarova
Publikováno v: Agrology, Vol 2, Iss 2, Pp 128-133 (2019)
In connection with the unbalanced nutrition of people, the constant psychological and physical stress of humankind, the spread of diseases of different etymologies, the growing of agricultural crops with high anthocyan content and the obtaining of an
Externí odkaz: https://doaj.org/article/72b0eee50fb2459bb81bb4f3d9b1bcad
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4
Akademický článek
Gonadoliberin – Synthesis, Secretion, Molecular Mechanisms and Targets of Action
Autor: A. O. Shpakov, K. V. Derkach
Publikováno v: Acta Biomedica Scientifica, Vol 4, Iss 2, Pp 7-15 (2019)
Decapeptide gonadoliberin (GnRH) is the most important regulator of the hypothalamic-pituitary-gonadal (HPG) axis that controls the synthesis and secretion of the luteinizing and follicle-stimulating hormones by gonadotrophs in the adenohypophysis. G
Externí odkaz: https://doaj.org/article/1bc802b67b7c4b10ba6bcb499c31f88e
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8
Application of an Allosteric Agonist of the Luteinizing Hormone Receptor for Reducing the Effective Dose of Gonadotropin in the Treatment of Androgen Deficiency in Rats with Type 1 Diabetes
Autor: A. A. Bakhtyukov, K. V. Derkach, V. N. Sorokoumov, A. O. Shpakov
Publikováno v: Journal Biomed. 18:72-78
In type 1 diabetes mellitus, the impaired testosterone synthesis in the testes leads to androgen deficiency. The long-term application of high gonadotropin doses for its correction decreases the sensitivity of luteinizing hormone/human chorionic gona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c390a9d6bc2ca9e8f41879d420604348
https://doi.org/10.33647/2074-5982-18-3-72-78
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9
Proinsulin C-peptide Improves metabolic and Hormonal Parameters in Rats with Type 2 Diabetes Mellitus Having Normal but not Elevated Insulin Levels
Autor: K. V. Derkach, V. M. Bondareva, N. E. Basova, A. O. Shpakov
Publikováno v: Journal Biomed. 18:90-94
In type 2 diabetes mellitus (DM2), the impaired functions of the brain insulin system are associated with the weakened insulin transport through the blood-brain barrier due to insulin resistance. Insulin deficiency in the brain can be corrected by in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c32236f88c4f2f1294594e31f71cfd74
https://doi.org/10.33647/2074-5982-18-3-90-94
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10
Hormonal and Metabolic Status of Male Rats with Metabolic Syndrome Model Induced by Interruption of Breastfeeding in the Early Postnatal Period
Autor: A. O. Shpakov, V. M. Bondareva, K. V. Derkach
Publikováno v: Journal Biomed. 18:67-71
A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at the age of 4-6 months. However, this neonatal MS model requires optimization and a detailed study into the metabolic and hormonal parameters of adult
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6146fc66694a4f347e37d925b5b768d8
https://doi.org/10.33647/2074-5982-18-3-67-71
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