Zobrazeno 1 - 10
of 154
pro vyhledávání: '"K Treiber"'
Autor:
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jon M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart MJ Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia YI Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Publikováno v:
eLife, Vol 7 (2018)
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://doaj.org/article/959198e7fd31440495c0d4c7cf3c5c06
Autor:
David H Drewry, Carrow I Wells, David M Andrews, Richard Angell, Hassan Al-Ali, Alison D Axtman, Stephen J Capuzzi, Jonathan M Elkins, Peter Ettmayer, Mathias Frederiksen, Opher Gileadi, Nathanael Gray, Alice Hooper, Stefan Knapp, Stefan Laufer, Ulrich Luecking, Michael Michaelides, Susanne Müller, Eugene Muratov, R Aldrin Denny, Kumar S Saikatendu, Daniel K Treiber, William J Zuercher, Timothy M Willson
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181585 (2017)
Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small
Externí odkaz:
https://doaj.org/article/ca1842e46c3c4d9282fcf8bc425a50a8
Akademický článek
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Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1727-1731
We demonstrate an innovative approach for optimization of kinase inhibitor potency and selectivity utilising kinase mini-panels and kinome-wide panels. We present a focused case study on development of a selective inhibitor of cyclin G associated kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ece83dc2f91e6405cad68e270b161a
https://doi.org/10.1016/j.bmcl.2019.05.025
https://doi.org/10.1016/j.bmcl.2019.05.025
Publikováno v:
Clinical Nutrition ESPEN. 46:S714
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3493d10fb3651c3c0b7c84ef5cc9140b
https://doi.org/10.1016/j.clnesp.2021.09.481
https://doi.org/10.1016/j.clnesp.2021.09.481
The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification
Autor:
Jinhua Wang, Kumar Singh Saikatendu, Christopher R. M. Asquith, Nathanael S. Gray, Timothy M. Willson, Caitlin E. Mills, Daniel K. Treiber, Stephanie B Hatch, Daniel Ebner, William J. Zuercher, Martin Schröder, Kristijan Ramadan, Alison D. Axtman, Peter Ettmayer, David M. Andrews, Santiago Vilar, Alfredo Picado, Shudong Lee, Michael R. Michaelides, Brandon J. Turunen, Dafydd R. Owen, David H. Drewry, Mathias Frederiksen, J.M. Elkins, Christian Fischer, Ivan Dikic, Susanne Müller, Hassan Al-Ali, Stefan Knapp, Carrow I. Wells, Ulrich Lücking, Mirra Chung, Alexandra Stolz, Maria Tellechea
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6db58ddd25edcc463870111b4a5e0b
Autor:
Daniel K. Treiber, Luis Gonzalez, Gabriel Pallares, Ksenya Cohen Katsenelson, Alastair J. King
Publikováno v:
Cancer Research. 80:6408-6408
E3 ligases have emerged as pivotal targets for a next generation protein degradation-based drug discovery paradigm. This new paradigm includes both ligand binding-directed “reprogramming” of E3 substrate specificity approaches and a more directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8570ce4abd4ff8a2e2a047366848426
https://doi.org/10.1158/1538-7445.am2020-6408
https://doi.org/10.1158/1538-7445.am2020-6408
We demonstrate an innovative approach utilising both fit-for-purpose kinase mini-panels and kinome-wide panels to progress discovery programs in the optimization of inhibitor potency and selectivity. We present a focused case study on development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa00698b3a15fcf27382ad10ca011048
https://doi.org/10.1101/471615
https://doi.org/10.1101/471615
Autor:
David H. Drewry, Steve Hitchcock, Volker Dötsch, Ingo Hartung, Brian D. Marsden, Hisanori Matsui, C. Bountra, Carrow I. Wells, Marcus Bauser, Stefan Knapp, Volkhart Mj Li, Amélia Yi Viana, Christian Fischer, Mathias John Paul, Adrian Carter, Spiros Liras, Julian Blagg, Mark Edward Bunnage, Suzanne Ackloo, Adriaan P. IJzerman, Susanne Müller, Stephen V. Frye, Saul H Rosenberg, Natalie S Schneider, Daniel K Treiber, Andreas Gollner, David R. Damerell, Cora Scholten, Bryan L. Roth, Cheryl H. Arrowsmith, Charles E. Grimshaw, Aled M. Edwards, Kumar Singh Saikatendu, Timothy M. Willson, Jeremy L Baryza, Thomas Hanke, Masayuki Takizawa, Peter Brown, Terry V Hughes, James P. Edwards, Daniel Rauh, Trevor Howe, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Chris Tse, Vineet Pande, Anton Simeonov, Paul R. Thompson, Dafydd R. Owen, J.M. Elkins, Jark Böttcher, William J. Zuercher, Stefan Laufer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d718f899c5ce6099584927eb7f1b37e
https://doi.org/10.7554/elife.34311.009
https://doi.org/10.7554/elife.34311.009
Autor:
Julian Blagg, David H. Drewry, Steve Hitchcock, Hisanori Matsui, Carrow I. Wells, Daniel Rauh, Anke Mueller-Fahrnow, Ronan C. O'Hagan, Adriaan P. IJzerman, Kumar Singh Saikatendu, Stefan Laufer, Timothy M. Willson, Paul R. Thompson, Chris Tse, Saul H Rosenberg, C. Bountra, Marcus Bauser, Dafydd R. Owen, Brian D. Marsden, Terry V Hughes, Daniel K Treiber, James P. Edwards, Bryan L. Roth, Cheryl H. Arrowsmith, Suzanne Ackloo, J.M. Elkins, Adrian Carter, Spiros Liras, Stefan Knapp, Christian Fischer, Susanne Müller, Amélia Yi Viana, Mathias John Paul, William J. Zuercher, Masayuki Takizawa, Jeremy L Baryza, Thomas Hanke, Peter Brown, David R. Damerell, Cora Scholten, Stephen V. Frye, Anton Simeonov, Mark Edward Bunnage, Charles E. Grimshaw, Andreas Gollner, Aled M. Edwards, Natalie S Schneider, Trevor Howe, Volker Dötsch, Ingo Hartung, Jark Böttcher, Vineet Pande, Volkhart Mj Li
Publikováno v:
eLife, Vol 7 (2018)
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
eLife
ELIFE, 7, e34311. ELIFE SCIENCES PUBLICATIONS LTD
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba91100a44a3d9b67ccf3f2841cb55bf