Zobrazeno 1 - 10
of 33
pro vyhledávání: '"K T Arndt"'
Autor:
Xin Han, Charles Ingalls, Russell Dushin, Middleton Brawner Floyd, Thomas Nittoli, Katherine Cheung, Yongbo Hu, K T Arndt, G. Grosu, Bing Guo, Heidi L. Fraser, Allan Wissner, Andrea Olland
Publikováno v:
European Journal of Medicinal Chemistry. 45:1379-1386
A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent and relatively selective inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a386fbdfbe585a340f415a4ed8d9f4f
https://doi.org/10.1016/j.ejmech.2009.12.036
https://doi.org/10.1016/j.ejmech.2009.12.036
Autor:
K T Arndt, Tarek S. Mansour, Osvaldo Dos Santos, Judy Lucas, Yi Geng, Zecheng Chen, Christoph Martin Dehnhardt, Lei Chen, Inder Chaudhary, Aranapakam Mudumbai Venkatesan, Efren Guillermo Delos Santos, Semiramis Ayral-Kaloustian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4980-4983
The synthesis and SAR of a series of 2,4-diamino-quinazoline derivatives as beta-catenin/Tcf-4 inhibitors are described. This series was developed by modifying the initial lead 1, which was identified by screening of our compound library and found to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732e0aaa65806086ce1e80048a88bfb1
https://doi.org/10.1016/j.bmcl.2009.07.070
https://doi.org/10.1016/j.bmcl.2009.07.070
Publikováno v:
Molecular Carcinogenesis. 48:678-684
Many anticancer agents activate NF-kappaB, which plays an important role in the survival of cancer cells. Inhibition of NF-kappaB activity may therefore potentiate the efficacy of anticancer agents. We found that a previously used anticancer agent St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f99a3af58db2b3c6ad00c3911c583bde
https://doi.org/10.1002/mc.20550
https://doi.org/10.1002/mc.20550
Autor:
Judy Lucas, Y. Zhang, Max Follettie, Maria Gavriil, K T Arndt, Veronica Diesl, Robert T. Abraham, Sreekala Mandiyan, Steve Haney, Dennis Powell, Fuk-Wah Sum
Publikováno v:
Cancer Research. 68:9519-9524
Tumor necrosis factor α (TNFα) has been used to treat patients with certain tumor types. However, its antitumor activity has been undermined by the activation of IκBα kinase (IKK), which in turn activates nuclear factor-κB (NF-κB) to help cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8af1c4789e629077359db80bca769d0
https://doi.org/10.1158/0008-5472.can-08-1549
https://doi.org/10.1158/0008-5472.can-08-1549
Autor:
Latha Sridharan, Judy Lucas, Carlo Etienne, Craig Titsch, Inder Chaudhary, Christine Huselton, Diane H. Boschelli, Jennifer M. Golas, Carolyn Discafani, Erwin R. Boghaert, Frank Boschelli, K T Arndt, Jonathan Golas, Fei Ye, Fangbiao Li
Publikováno v:
Cancer Research. 65:5358-5364
Src up-regulation is a common event in human cancers. In colorectal cancer, increased Src levels are an indicator of poor prognosis, and progression to metastatic disease is associated with substantial increases in Src activity. Therefore, we examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8dbf321e875be4b51a22f7f06ec9d92
https://doi.org/10.1158/0008-5472.can-04-2484
https://doi.org/10.1158/0008-5472.can-04-2484
Autor:
Blegen C, George B. Segel, K T Arndt, Joanna Kaminska, Bethlendy G, Della Seta F, Teresa Zoladek, Swiderek Km, Lin P, Kabir Ma, Fred Sherman
Publikováno v:
Yeast. 22:219-239
Eukaryotic chaperonins, the Cct complexes, are assembled into two rings, each of which is composed of a stoichiometric array of eight different subunits, which are denoted Cct1p-Cct8p. Overexpression of a single CCT gene in Saccharomyces cerevisiae c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe22ccdfe9f5a5137d1d03a519d2346
https://doi.org/10.1002/yea.1210
https://doi.org/10.1002/yea.1210
Publikováno v:
Molecular Cell. 8(5):1017-1026
In Saccharomyces cerevisiae, the rapamycin-sensitive TOR kinases negatively regulate the type 2A-related phosphatase SIT4 by promoting the association of this phosphatase with the inhibitor TAP42. Here, we describe TIP41, a conserved TAP42-interactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc87e906398ad5692837415f273aac72
Autor:
James D. Friesen, K T Arndt, Jean H. Kawasoe, David B. Jansma, Jack Greenblatt, Jacques Archambault
Publikováno v:
Journal of Bacteriology. 180:2590-2598
Mutations that increase the low-level transcription of the Saccharomyces cerevisiae HIS4 gene, which results from deletion of the genes encoding transcription factors BAS1, BAS2, and GCN4, were isolated previously in SIT1 (also known as RPO21 , RPB1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4665506eb53617e26a1e93d2f84cd1f6
https://doi.org/10.1128/jb.180.10.2590-2598.1998
https://doi.org/10.1128/jb.180.10.2590-2598.1998
Publikováno v:
Journal of Biological Chemistry. 271:1349-1356
The Saccharomyces cerevisiae SIS1 gene encodes an essential heat shock protein with similarity to the Escherichia coli DnaJ protein. In sis 1-85 and sis1-86 mutants, the sis1 RNA is induced to high levels at room temperature and without heat shock. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019e65f7ad9c942d6c380dffebde6375
https://doi.org/10.1074/jbc.271.3.1349
https://doi.org/10.1074/jbc.271.3.1349
Autor:
K T Arndt, A I Doseff
Publikováno v:
Genetics. 141:857-871
Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3346cb6e44f2cee0d3cfdaab890fc8
https://doi.org/10.1093/genetics/141.3.857
https://doi.org/10.1093/genetics/141.3.857