Zobrazeno 1 - 10
of 22
pro vyhledávání: '"K T, Shiverick"'
Publikováno v:
Endocrinology. 140(10)
Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal models show that males have higher incidences of gastric cancers compared with females, suggesting that sex hormones may modulate gastric cancer risk.
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
This study examined the effect of chronic cocaine exposure on selected immune parameters in pregnant rats. Cocaine hydrochloride, 60 mg/kg, was administered by i.p. injection as a divided daily dose on gestation days 8 to 19. This cocaine treatment r
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 270(1)
This study evaluated the effects of chronic exposure to cocaine during pregnancy on the morphology and function of the placenta. Pregnant rats received either 45 or 60 mg/kg of cocaine hydrochloride by i.p. injection as a divided daily dose on days 8
Autor:
H A, Schut, K T, Shiverick
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 6(11)
The quantitation of adducts of genotoxins with DNA is probably one of the best indicators of genetic damage due to exposure to toxins or carcinogens. It is generally believed that such adducts can lead to mutations, which in turn can trigger the init
Publikováno v:
Molecular pharmacology. 37(2)
Studies investigated the effects of benzo(a)pyrene (BP) treatment on epidermal growth factor (EGF) receptor binding and kinase activity in human placental cell cultures. Specific binding of 125I-EGF to cells from early gestation placentae was signifi
Publikováno v:
Endocrinology. 126(1)
Human pregnancy-specific beta 1-glycoprotein (PS beta G) is synthesized in large quantities by syncytiotrophoblasts of the placenta. Recent studies using a partial cDNA of PS beta G isolated from human term placenta detected the presence of mRNA high
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 227(1)
Administration of low doses of beta-naphthoflavone (beta-NF) to pregnant rats on days 7 to 14 of gestation has been associated with extensive fetal mortality. Studies were conducted to evaluate the effects of beta-NF administration on several extrahe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 221(3)
The effects of chronic treatment with thyroxine (T4) and estradiol on hepatic microsomal metabolism of estrogens to catechol products were studied and the extent to which activity in vitro correlated with serum estradiol concentrations in vivo was as
Publikováno v:
Molecular pharmacology. 34(3)
Studies characterized insulin and EGF receptors in human placental tissue from smokers and nonsmokers. Specific binding of 125I-labeled insulin and EGF to placental membranes was not different for nonsmokers compared with smokers. EGF and insulin rec
Autor:
K T, Shiverick, M, Notelovitz
Publikováno v:
Biochemical pharmacology. 32(16)
Experiments were conducted to evaluate whether estrogen 2-hydroxylase activity in liver microsomes, the main pathway for oxidative metabolism of estrogens in the rat, is regulated by administration of synthetic estrogens. Ovariectomized rats were tre