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pro vyhledávání: '"K T, Goldsmith"'
Publikováno v:
Gene therapy. 3(11)
Previous work by this group has established that E1-defective, recombinant adenoviruses can be replication-enabled by the codelivery of a plasmid encoding the deleted E1 functions, a strategy now designated conditional replication-enablement system f
Publikováno v:
Cancer gene therapy. 3(4)
Achieving limited recombinant viral replication may provide a means of amplifying viral-mediated gene transfer in vivo. We have previously shown that cotransduction of an E1-defective adenovirus with a plasmid containing the deleted E1 functions into
Publikováno v:
Gene therapy. 1(1)
Carcinomas are malignancies derived from epithelial cells that frequently respond poorly to conventional chemotherapy. Selective expression or transduction of toxin genes to carcinomas, i.e. molecular chemotherapy, may offer important advantages over
Autor:
K. T. Goldsmith, C. S. Pace
Publikováno v:
American Journal of Physiology-Cell Physiology. 248:C527-C534
The possible role of protein kinase c in regulating the electrical events in the B-cell plasma membrane was examined by using the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), a known activator of this enzyme. TPA has been found to enhan