Zobrazeno 1 - 9 of 9 pro vyhledávání: '"K T, Chapman"'
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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
Autor: N A, Thornberry, T A, Rano, E P, Peterson, D M, Rasper, T, Timkey, M, Garcia-Calvo, V M, Houtzager, P A, Nordstrom, S, Roy, J P, Vaillancourt, K T, Chapman, D W, Nicholson
Publikováno v: The Journal of biological chemistry. 272(29)
There is compelling evidence that members of the caspase (interleukin-1beta converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis. Here we use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec834dddf3c7a76da30f42cac465fbb3
https://pubmed.ncbi.nlm.nih.gov/9218414
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3
A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo
Autor: D S, Fletcher, L, Agarwal, K T, Chapman, J, Chin, L A, Egger, G, Limjuco, S, Luell, D E, MacIntyre, E P, Peterson, N A, Thornberry
Publikováno v: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 15(3)
A potent, reversible, tetrapeptide inhibitor of interleukin-1 beta converting enzyme (ICE), L-709,049, has been shown to suppress the in vitro production of mature IL-1 beta. We now report that this inhibitor also effectively suppresses the productio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::211a3731cbad6946fd3b147ec5936d32
https://pubmed.ncbi.nlm.nih.gov/7584670
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4
Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydride
Autor: Erick M. Carreira, David A. Evans, K. T. Chapman
Publikováno v: Journal of the American Chemical Society. 110:3560-3578
The mild reducing agent tetramethylammonium triacetoxyborohydride reduces acyclic P-hydroxy ketones to their corresponding anti diols with high diastereoselectivity. a-Alkyl substitution does not significantly affect the stereoselectivity of these re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8dea854e4829df58bd8ef760f198899
https://doi.org/10.1021/ja00219a035
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5
New asymmetric Diels-Alder cycloaddition reactions. Chiral .alpha.,.beta.-unsaturated carboximides as practical chiral acrylate and crotonate dienophile synthons
Autor: J. Bisaha, K. T. Chapman, David Evans
Publikováno v: Journal of the American Chemical Society. 106:4261-4263
isolated material with the indicated diastereomer purity. crystalline crotonate imides 1b-3b were obtained in 80-90% yields from the lithiated 2-oxazolidones and (E)-2-butenoyl chloride in direct analogy with previously reported N-acylation pr~edures
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25a420509bee5a4d82aa716d10d9a861
https://doi.org/10.1021/ja00327a031
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