Zobrazeno 1 - 10
of 7 142
pro vyhledávání: '"K Sano"'
Autor:
Hidetaka S. Oshima, Akiko Ogawa, Fumiya K. Sano, Hiroaki Akasaka, Tomoyoshi Kawakami, Aika Iwama, Hiroyuki H. Okamoto, Chisae Nagiri, Fan-Yan Wei, Wataru Shihoya, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Adenosine receptors play pivotal roles in physiological processes. Adenosine A3 receptor (A3R), the most recently identified adenosine receptor, is expressed in various tissues, exhibiting important roles in neuron, heart, and immune cells,
Externí odkaz:
https://doaj.org/article/99446d64f226488b9b7aa4c54a21e170
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Lysophosphatidic acid receptor 1 (LPA1) is one of the G protein-coupled receptors activated by the lipid mediator, lysophosphatidic acid (LPA). LPA1 is associated with a variety of diseases, and LPA1 agonists have potential therapeutic value
Externí odkaz:
https://doaj.org/article/b2f93217f4244971b18306e71f79fe35
Autor:
Takaaki A. Kobayashi, Hiroto Shimada, Fumiya K. Sano, Yuzuru Itoh, Sawako Enoki, Yasushi Okada, Tsukasa Kusakizako, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an antioxidant against oxidative stress. As some mammals including humans cannot synthesize vitamin C de novo from glucose, its uptake from dietary sources is e
Externí odkaz:
https://doaj.org/article/f5a87d612bbc4dee96b6a0b432ab3cc5
Autor:
Aika Iwama, Ryoji Kise, Hiroaki Akasaka, Fumiya K. Sano, Hidetaka S. Oshima, Asuka Inoue, Wataru Shihoya, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-amide motif. QRFP selectively activates a class A G-protein-coupled receptor (GPCR) GPR103 to exert various physiological functions such as energy metabolism
Externí odkaz:
https://doaj.org/article/b6422e77482146409dd13929fed4321c
Autor:
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K. Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H. Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract GPR34 is a recently identified G-protein coupled receptor, which has an immunomodulatory role and recognizes lysophosphatidylserine (LysoPS) as a putative ligand. Here, we report cryo-electron microscopy structures of human GPR34-Gi complex
Externí odkaz:
https://doaj.org/article/bceac4aee4d24bd1b9b9d0c676409f20
Publikováno v:
Journal of Orthopaedic Surgery, Vol 12 (2004)
Purpose. To study operative treatment and postoperative clinical outcomes of hip fracture in haemodialysed patients. Methods. In 12 patients (8 men and 4 women) undergoing haemodialysis, 14 hip fractures were treated. Of these, 8 hips were treated wi
Externí odkaz:
https://doaj.org/article/a7afb5a424404df4a7be907a3a3fde4d
Autor:
Hiroaki Akasaka, Tatsuki Tanaka, Fumiya K. Sano, Yuma Matsuzaki, Wataru Shihoya, Osamu Nureki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
LPA1 is one of the GPCRs that are drug targets for various diseases. Here the authors report a cryo-EM structure of the active human LPA1-Gi complex bound to an LPA analog with more potent activity against LPA1 and clarified the ligand recognition me
Externí odkaz:
https://doaj.org/article/c158723943634b34b5e11430cdadd030
Publikováno v:
eLife, Vol 12 (2023)
The endothelin ETB receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ETB signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle. Consequently, ETB agonis
Externí odkaz:
https://doaj.org/article/974f9b1bae11462d96a08284fd654289
Autor:
Ariel Chazan, Ishita Das, Takayoshi Fujiwara, Shunya Murakoshi, Andrey Rozenberg, Ana Molina-Márquez, Fumiya K. Sano, Tatsuki Tanaka, Patricia Gómez-Villegas, Shirley Larom, Alina Pushkarev, Partha Malakar, Masumi Hasegawa, Yuya Tsukamoto, Tomohiro Ishizuka, Masae Konno, Takashi Nagata, Yosuke Mizuno, Kota Katayama, Rei Abe-Yoshizumi, Sanford Ruhman, Keiichi Inoue, Hideki Kandori, Rosa León, Wataru Shihoya, Susumu Yoshizawa, Mordechai Sheves, Osamu Nureki, Oded Béjà
Publikováno v:
Nature. 615:535-540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297adddd95c5f56318e03205ce98d29d
https://doi.org/10.1038/s41586-023-05774-6
https://doi.org/10.1038/s41586-023-05774-6
