Zobrazeno 1 - 10
of 286
pro vyhledávání: '"K S Yeung"'
Autor:
Gordon K C Leung, Christopher C Y Mak, Jasmine L F Fung, Wilfred H S Wong, Mandy H Y Tsang, Mullin H C Yu, Steven L C Pei, K S Yeung, Gary T K Mok, C P Lee, Amelia P W Hui, Mary H Y Tang, Kelvin Y K Chan, Anthony P Y Liu, Wanling Yang, P C Sham, Anita S Y Kan, Brian H Y Chung
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Whole-exome sequencing (WES) has become an invaluable tool for genetic diagnosis in paediatrics. However, it has not been widely adopted in the prenatal setting. This study evaluated the use of WES in prenatal genetic diagnosis in
Externí odkaz:
https://doaj.org/article/282d5793434f48b0ae2433ea3829b919
Autor:
Mianne, Lee, Adrian C Y, Lui, Christopher C Y, Mak, Mandy H Y, Tsang, Jasmine L F, Fung, K S, Yeung, Brian Hon Yin, Chung
Publikováno v:
Clinical Dysmorphology. 31:113-124
Mosaicism refers to the coexistence of two or more genetically distinct cell populations in an individual from a single fertilized egg. We performed a retrospective analysis of all patients diagnosed with mosaic disorders between 2010 and 2021 in a u
Autor:
Yugang Liu, Lei Zhang, Oliver Simon, Peichao Lu, Fumiaki Yokokawa, Kevin Hung, Christopher Sarko, Bryan K. S. Yeung
Publikováno v:
Synlett. 33:464-467
A synthesis of the first-in-class pan-serotype dengue virus inhibitor NITD-688 is presented. The Gewald reaction of N-(tert-butoxycarbonyl)-6,6-dimethylpiperidin-3-one with malononitrile and sulfur in the presence of l-proline as a catalyst gave tert
Autor:
Thomas H. Keller, Bryan K. S. Yeung, Louis-Sebastian Sonntag, Seh Yong Leong, Peiling Yap, Bin Zou
Publikováno v:
Molecules, Vol 17, Iss 9, Pp 10131-10141 (2012)
During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the 4E and 4Z imine intermediates, a systematic mechanistic study of the reacti
Externí odkaz:
https://doaj.org/article/71cc1611625b4dafbe7ac8b228504515
Akademický článek
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Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Hongping Dong, Bryan K. S. Yeung, Ratna Karuna, Bin Zou, Trixie Wagner, Hui-Quan Yeo, Cyrille Kounde, Oliver Simon, Kah Fei Wan, Qing-Yin Wang, Ghislain M. C. Bonamy, Fumiaki Yokokawa, Ina Dix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1385-1389
A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the i
Autor:
Kevin S. W. Tan, Kate Breyer, Georges Snounou, Clemens H. M. Kocken, Anne Elliot, Bruce Russell, Varakorn Kosaisavee, Bryan K. S. Yeung, Bee Huat Tan, Adeline C. Y. Chua, Rossarin Suwanarusk, Siti Nurdiana Abas, Rou Zhang, Anne-Marie Zeeman, Jee Sun Cho, Benoit Malleret, Laurent Rénia, Roger Le Grand, Dennis E. Kyle, Mary R. Galinski, Christophe Bodenreider, Nathalie Dereuddre-Bosquet, Chester J. Joyner, François Nosten, Dominique Mazier, Szczepan W Baran, Pablo Bifani, Amber Lange, Jessica Jie Ying Ong, Thierry T. Diagana, Steven P. Maher, Caitlin A. Cooper, Andy M. Yip
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
The ability to culture pathogenic organisms substantially enhances the quest for fundamental knowledge and the development of vaccines and drugs. Thus, the elaboration of a protocol for the in vitro cultivation of the erythrocytic stages of Plasmodiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd9b03ad20049d99276309712f02ba
https://hal.archives-ouvertes.fr/hal-02347287
https://hal.archives-ouvertes.fr/hal-02347287
Autor:
Els J. Klooster, Oliver Simon, Thierry T. Diagana, Suresh B. Lakshminarayana, Bryan K. S. Yeung, Anne-Marie Zeeman, Christophe Bodenreider, Robert W. Sauerwein, Ravinder Reddy Kondreddi, Nicole van der Werff, Annemarie Voorberg-van der Wel, Clemens H. M. Kocken
Publikováno v:
Antimicrobial Agents and Chemotherapy, 60, 2858-63
Antimicrobial Agents and Chemotherapy, 60, 5, pp. 2858-63
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 60, 5, pp. 2858-63
Antimicrobial Agents and Chemotherapy
Two Plasmodium PI4 kinase (PI4K) inhibitors, KDU691 and LMV599, were selected for in vivo testing as causal prophylactic and radical-cure agents for Plasmodium cynomolgi sporozoite-infected rhesus macaques, based on their in vitro activity against li
Autor:
Francesca Blasco, Suresh B. Lakshminarayana, Thierry T. Diagana, Jing Yu, Christoph Fischli, Sebastian Weber, Paul C. Ho, Matthias Rottmann, Véronique Dartois, Bryan K. S. Yeung, Céline Freymond, Anne Goh
Publikováno v:
Antimicrobial Agents and Chemotherapy
Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone