Výsledky vyhledávání

The role of genetic toxicology in drug discovery and optimization

Autor: K S Sweder, L L Custer

Publikováno v: Current drug metabolism. 9(9)

Genetic toxicology data is used as a surrogate for long-term carcinogenicity data during early drug development. The aim of genotoxicity testing is to identify potentially hazardous drug candidates. Results from genetic toxicology tests in combinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f952bf7edc4d40617abecb5ca492ae
https://pubmed.ncbi.nlm.nih.gov/18991595

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The participation of AtXPB1, the XPB/RAD25 homologue gene from Arabidopsis thaliana, in DNA repair and plant development

Autor: R M, Costa, P G, Morgante, C M, Berra, M, Nakabashi, D, Bruneau, D, Bouchez, K S, Sweder, M A, Van Sluys, C F, Menck

Publikováno v: The Plant journal : for cell and molecular biology. 28(4)

Nucleotide excision repair in Arabidopsis thaliana differs from other eukaryotes as it contains two paralogous copies of the corresponding XPB/RAD25 gene. In this work, the functional characterization of one copy, AtXPB1, is presented. The plant gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2701539ad4464b312ff617874e8ee932
https://pubmed.ncbi.nlm.nih.gov/11737776

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The COOH terminus of suppressor of stem loop (SSL2/RAD25) in yeast is essential for overall genomic excision repair and transcription-coupled repair

Autor: K S, Sweder, P C, Hanawalt

Publikováno v: The Journal of biological chemistry. 269(3)

We examined several yeast strains with different mutations in the essential SSL2 (Suppressor of Stem Loop, also called RAD25) gene for their ability to remove cyclobutane pyrimidine dimers from expressed genes, and from the genome overall. The SSL2 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::244b53cdbe87688702e70a1745c38473
https://pubmed.ncbi.nlm.nih.gov/8294433

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Purification and characterization of proteins that bind to yeast ARSs

Autor: K S, Sweder, P R, Rhode, J L, Campbell

Publikováno v: The Journal of biological chemistry. 263(33)

Two proteins that bind to yeast ARS DNA have been purified using conventional and oligonucleotide affinity chromatography. One protein has been purified to homogeneity and has a mass of 135 kDa. Competitive binding studies and DNase I footprinting sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0eb136269431906718eb75ddd79253b9
https://pubmed.ncbi.nlm.nih.gov/3053706

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