Výsledky vyhledávání

Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase

Autor: G A Timony, Glenn R. Larsen, K S Henson, J B Stoudemire, P G Horgan, K M Barone, L B Angus

Publikováno v: Journal of Biological Chemistry. 266:8156-8161

Human tissue-type plasminogen activator (t-PA) is a glycoprotein used currently in thrombolytic therapy for patients with acute myocardial infarction. Due to its rapid rate of clearance from the circulation, continuous intravenous administration of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2475c0babdb575e780a7ebe01126aade
https://doi.org/10.1016/s0021-9258(18)92955-8

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Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation

Autor: L B Angus, J B Stoudemire, Ahern Tim J, G A Timony, G E Morris, K S Henson, P G Horgan, K M Barone, P R Langer-Safer, Glenn R. Larsen

Publikováno v: Journal of Biological Chemistry. 265:5540-5545

Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eba31d8307d684ad1449c473dc2a798d
https://doi.org/10.1016/s0021-9258(19)39394-9

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Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase

Autor: G R, Larsen, G A, Timony, P G, Horgan, K M, Barone, K S, Henson, L B, Angus, J B, Stoudemire

Publikováno v: The Journal of biological chemistry. 266(13)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0cf739790706c067bf6f81ac9069ea1
https://pubmed.ncbi.nlm.nih.gov/1708773

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Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation

Autor: T J, Ahern, G E, Morris, K M, Barone, P G, Horgan, G A, Timony, L B, Angus, K S, Henson, J B, Stoudemire, P R, Langer-Safer, G R, Larsen

Publikováno v: The Journal of biological chemistry. 265(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::449dc56bdfee8ee11724a1009bd4efe5
https://pubmed.ncbi.nlm.nih.gov/2108143

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Variants of human tissue-type plasminogen activator. Fibrin binding, fibrinolytic, and fibrinogenolytic characterization of genetic variants lacking the fibronectin finger-like and/or the epidermal growth factor domains

Autor: Glenn R. Larsen, Yitzhak Blue, K S Henson

Publikováno v: Journal of Biological Chemistry. 263:1023-1029

Tissue-type plasminogen activator (t-pa) is a serine protease comprising four different putative structural domains with homologies to fibronectin finger-like structures (finger), epidermal growth factor, kringle structures, and the active site of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a82e2b2764fe6ff9b815601e308331c
https://doi.org/10.1016/s0021-9258(19)35456-0

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Distinguishing the sites in the amino-terminal region of tissue-type plasminogen activator (T-PA) required for efficient fibrinolytic activity and rapid clearance from the circulation

Autor: T.J. Ahem, G E Morris, K M Barone, L B Angus, K S Henson, P G Horgan, Glenn R. Larsen, P.R. Larger-Safer

Publikováno v: Fibrinolysis. 3:5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d1f79429627a8580be2879584949752
https://doi.org/10.1016/0268-9499(89)90069-6

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