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pro vyhledávání: '"K S, Para"'
Autor:
K S, Para, T K, Sawyer
Publikováno v:
Methods in molecular medicine. 23
Aminobenzoic acid-based congeners are emerging as a useful class of nonpeptide templates for applications in peptidomimetic drug discovery. Exemplifying such compounds are recently described antagonists or inhibitors of several receptor and signal tr
Autor:
J V, Prasad, E A, Lunney, K S, Para, P J, Tummino, D, Ferguson, D, Hupe, J M, Domagala, J W, Erickson
Publikováno v:
Drug design and discovery. 13(3-4)
From an initial mass screening lead, (IC50: 3 microM) and information derived from the X-ray crystallographic structure of a related analog, complexed with HIV protease (PR), the design of more potent inhibitors has been advanced. Various structure-g
Autor:
M S, Plummer, E A, Lunney, K S, Para, J V, Prasad, A, Shahripour, J, Singh, C J, Stankovic, C, Humblet, J H, Fergus, J S, Marks, T K, Sawyer
Publikováno v:
Drug design and discovery. 13(3-4)
Src homology-2 (SH2) domains, containing approximately 100 amino acid residues, are noncatalytic motifs involved with intracellular signal transduction. These domains can be found on nonreceptor kinases, phosphatases, and in regulatory adapter protei
Autor:
J V, Prasad, K S, Para, P J, Tummino, D, Ferguson, T J, McQuade, E A, Lunney, S T, Rapundalo, B L, Batley, G, Hingorani, J M, Domagala
Publikováno v:
Journal of medicinal chemistry. 38(6)
Using molecular modeling and the information derived from the X-ray crystal structure of HIV-1 protease (HIV PR) complexed with the pyran-2-one 1, a series of (4-hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes was designed and analyzed as novel, no