Zobrazeno 1 - 10
of 11
pro vyhledávání: '"K S, Koblan"'
Autor:
John J. Renger, John Palcza, Nagaaki Sato, Robert Iannone, A Buntinx, B R Bloem, R H Hargreaves, Rik C. Schoemaker, K S Koblan, Laura B. Rosen, Adam F. Cohen, J.M.A. van Gerven, Chodakewitz Jeffrey A, Keith Gottesdiener, Remco W. M. Zoethout, Sabrina Marsilio, Shigeru Tokita, Gail Murphy, K Van Dyck, E D Louis
Publikováno v:
Journal of Psychopharmacology, 26, 2, pp. 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302
Item does not contain fulltext Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA
Autor:
B. Hoyle, K. S. Koblan
Publikováno v:
MD Conference Express. 15:3-4
Autor:
K R, Oliver, S A, Kane, C A, Salvatore, J J, Mallee, A M, Kinsey, K S, Koblan, N, Keyvan-Fouladi, R P, Heavens, A, Wainwright, M, Jacobson, I M, Dickerson, R G, Hill
Publikováno v:
The European journal of neuroscience. 14(4)
Calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), amylin and calcitonin (CT) are structurally and functionally related neuropeptides. It has recently been shown that the molecular pharmacology of CGRP and ADM is determined by coexpression
Autor:
Y T, Shen, T J, Pittman, P S, Buie, D L, Bolduc, S A, Kane, K S, Koblan, R J, Gould, J J, Lynch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(2)
It remains unknown whether the extent of vasoactive response to exogenous calcitonin gene-related peptide (CGRP) varies among different regional vascular beds. It is also unclear whether endogenous CGRP plays a functional role in regulating basal vas
Autor:
C A, Omer, Z, Chen, R E, Diehl, M W, Conner, H Y, Chen, M E, Trumbauer, S, Gopal-Truter, G, Seeburger, H, Bhimnathwala, M T, Abrams, J P, Davide, M S, Ellis, J B, Gibbs, I, Greenberg, K S, Koblan, A M, Kral, D, Liu, R B, Lobell, P J, Miller, S D, Mosser, T J, O'Neill, E, Rands, M D, Schaber, E T, Senderak, A, Oliff, N E, Kohl
Publikováno v:
Cancer research. 60(10)
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme farnesyl:protein transferase (FPTase). Inhibitors of FPTase have therefore been developed as pote
Autor:
M J, Bogusky, J C, Culberson, S M, Pitzenberger, V M, Garsky, A, Wallace, A, Pessi, K S, Koblan
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 54(1)
Farnesyl-protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the C-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for membrane association and cell-tran
Autor:
R B, Lingham, K C, Silverman, H, Jayasuriya, B M, Kim, S E, Amo, F R, Wilson, D J, Rew, M D, Schaber, J D, Bergstrom, K S, Koblan, S L, Graham, N E, Kohl, J B, Gibbs, S B, Singh
Publikováno v:
Journal of medicinal chemistry. 41(23)
We have identified a novel fungal metabolite that is an inhibitor of human farnesyl-protein transferase (FPTase) by randomly screening natural product extracts using a high-throughput biochemical assay. Clavaric acid [24, 25-dihydroxy-2-(3-hydroxy-3-
Publikováno v:
Methods in enzymology. 210
Autor:
K S, Koblan, G K, Ackers
Publikováno v:
Biochemistry. 30(31)
The effects of monovalent salt activity on the site-specific and cooperative interactions of cI repressor with its three operator sites OR were studied by using quantitative DNase I footprint titration methods. Individual-site binding isotherms were
Publikováno v:
Journal of Biological Chemistry. 261:772-778
A series of plasmids encoding various Klebsiella pneumoniae nif (nitrogen fixation) genes were constructed to determine which were required to produce active iron (Fe) protein in Escherichia coli, a species which does not normally fix nitrogen. The g