Zobrazeno 1 - 10
of 29
pro vyhledávání: '"K S, Kasprzak"'
Publikováno v:
Archives of Biochemistry and Biophysics. 302:294-299
Free radical generation from H2O2 and lipid hydroperoxides in the presence of Cr(III) was investigated by electron spin resonance (ESR) spin trapping methodology. Incubation of Cr(III) with H2O2 at physiological pH generated hydroxyl (.OH) radical, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3179403fa1e1b12ba314a30dafede72b
https://doi.org/10.1006/abbi.1993.1213
https://doi.org/10.1006/abbi.1993.1213
Publikováno v:
Roczniki Akademii Medycznej w Bialymstoku (1995). 45
Susceptibility to spontaneous or chemically-induced liver tumors in mice has been demonstrated to be strain dependent, with the tumor development or promotion phase contributing most to variability. Since reactive oxygen species are thought to play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dab7c0fa6b1f2dfc8ac88a64f724e426
https://pubmed.ncbi.nlm.nih.gov/11712422
https://pubmed.ncbi.nlm.nih.gov/11712422
Publikováno v:
Annals of clinical and laboratory science. 31(1)
The murine MTH1 gene codes for MTH1, an 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) which hydrolyzes 8-oxo-dGTP, a promutagenic product of reactive oxygen species' attack on the nucleotide pool. This gene is regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08b73091f5a80bf1d7020d0ca39e5afa
https://pubmed.ncbi.nlm.nih.gov/11314867
https://pubmed.ncbi.nlm.nih.gov/11314867
Publikováno v:
Research communications in molecular pathology and pharmacology. 106(1-2)
Nonradioactive methods in comparison to those using radionuclides are now becoming popular because of safety, environmental, and cost concerns. The modified technique described here is much faster, easier, and safer than the conventional procedure ut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cec5c371e80b256d21d1423b5302860
https://pubmed.ncbi.nlm.nih.gov/11127802
https://pubmed.ncbi.nlm.nih.gov/11127802
Autor:
G S, Buzard, K S, Kasprzak
Publikováno v:
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 19(3)
Toxic doses of transition metals are capable of disturbing the natural oxidation/reduction balance in cells through various mechanisms stemming from their own complex redox reactions with endogenous oxidants and effects on cellular antioxidant system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bd66a23d45aa11f3e50789ff52157e0
https://pubmed.ncbi.nlm.nih.gov/10983886
https://pubmed.ncbi.nlm.nih.gov/10983886
Autor:
K. S. Kasprzak
Publikováno v:
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment ISBN: 9789401064408
This paper presents evidence that genotoxic and carcinogenic effects of certain transition metals are associated with oxidative damage to DNA and nuclear proteins. The metals, including Ni, Cr, and Co, are capable of causing promutagenic lesions, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d6ac8135d227430a7d9d961d230ef2
https://doi.org/10.1007/978-94-011-5780-3_5
https://doi.org/10.1007/978-94-011-5780-3_5
Autor:
W. Bal, K. S. Kasprzak
Publikováno v:
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment ISBN: 9789401064408
This paper presents results of studies on interactions of carcinogenic nickel with -CAIH-, a potential metal binding motif in nuclear chromatin. Structural and mechanistic results are discussed in the perspective of various concepts in nickel carcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e4d2af5779211d72b9e69a8e358625
https://doi.org/10.1007/978-94-011-5780-3_7
https://doi.org/10.1007/978-94-011-5780-3_7
Autor:
K. S. Kasprzak
Publikováno v:
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment ISBN: 9789401064408
This paper reviews the investigations on interactions between nickel and calcium, magnesium, zinc, or iron, aimed at elucidation of the mechanisms of nickel carcinogenesis and its prevention. Depending on the animal species, target tissues, particula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa31dc14aac8a5e7dac3f4334dc878cc
https://doi.org/10.1007/978-94-011-5780-3_6
https://doi.org/10.1007/978-94-011-5780-3_6
Publikováno v:
Journal of inorganic biochemistry. 64(4)
1-deoxynojirimycin (DNJ), a 5-imino analog of 1-deoxyglucose, is a potent inhibitor of alpha-glucosidase 1. DNJ and its derivatives have been considered as experimental drugs against human HIV-1 and hepatitis B viruses. Since amino and imino ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9180b6b856e3a72fa6ade0f76f83a0d1
https://pubmed.ncbi.nlm.nih.gov/8916412
https://pubmed.ncbi.nlm.nih.gov/8916412
Autor:
F W, Sunderman, A H, Varghese, O S, Kroftova, S, Grbac-Ivankovic, J, Kotyza, A K, Datta, M, Davis, W, Bal, K S, Kasprzak
Publikováno v:
Molecular reproduction and development. 44(4)
A Ni(II)-binding serpin, pNiXa, is abundant in Xenopus oocytes and embryos. Kinetic assays show that purified pNiXa strongly inhibits bovine alpha-chymotrypsin (Ki = 3 mM), weakly inhibits porcine elastase (K1 = 0.5 microM), and does not inhibit bovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70e8a1fa543a39b43199da2db6d7b593
https://pubmed.ncbi.nlm.nih.gov/8844694
https://pubmed.ncbi.nlm.nih.gov/8844694