Zobrazeno 1 - 10 of 25 pro vyhledávání: '"K S, Giacoletto"'
1
Differential effects of CTLA-4 substitutions on the binding of human CD80 (B7-1) and CD86 (B7-2)
Autor: P A Morton, X T Fu, J A Stewart, K S Giacoletto, S L White, C E Leysath, R J Evans, J J Shieh, R W Karr
Publikováno v: The Journal of Immunology. 156:1047-1054
CTLA-4 expressed on activated T cells binds to CD80 (B7-1) and CD86 (B7-2) molecules present on APC with high avidity and appears to deliver a negative regulatory signal to the T cell. We have investigated the kinetics of CTLA-4 binding to CD80 and C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faafb5a3f8672f5cf013455b7dbf262b
https://doi.org/10.4049/jimmunol.156.3.1047
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2
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation
Autor: R. J. Evans, R.W. Karr, Thomas J. Girard, K. S. Giacoletto, John L. Trotter, Anne H. Cross, Robin F. Lin, Richard M. Keeling
Publikováno v: Journal of Clinical Investigation. 95:2783-2789
T cell activation involves not only recognition of antigen presented by the MHC, but also nonspecific interactions termed "costimulation." The costimulatory molecules B7-1 and B7-2 are ligands on antigen-presenting cells for the CD28 and CTLA-4 recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60c372dcd62b6339101c4e0db9b68158
https://doi.org/10.1172/jci117982
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3
Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells
Autor: P A Morton, M L Zacheis, K S Giacoletto, J A Manning, B D Schwartz
Publikováno v: The Journal of Immunology. 154:137-150
The intracellular trafficking, proteolysis, and dissociation of invariant chain (li) associated with nascent class II molecules was examined in B-lymphoblastoid cells. Metabolic labeling and Percoll gradient centrifugation was used to assess the kine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f692ae35d8d3e167bc9206fc8195be80
https://doi.org/10.4049/jimmunol.154.1.137
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4
Peptide binding to surface class II molecules is the major pathway of formation of immunogenic class II-peptide complexes for viable antigen presenting cells
Autor: N R Nygard, K S Giacoletto, C Bono, J Gorka, S Kompelli, B D Schwartz
Publikováno v: The Journal of Immunology. 152:1082-1093
Although studies on fixed APCs have demonstrated that peptide can bind to cell surface class II molecules, the mechanisms by which peptide-class II complexes are formed in viable cells is largely unexplored. To explore the possibility that peptide lo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::017b33ac818ab7a6bde1bb445d3fd6bc
https://doi.org/10.4049/jimmunol.152.3.1082
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5
Antibody recognition of an immunogenic influenza hemagglutinin-human leukocyte antigen class II complex
Autor: Vivian L. Braciale, K S Giacoletto, N R Nygard, J Gorka, D W McCourt, W T Schaiff, L R Brown, C Bono, Mary Beth Graham, M Kabeer
Publikováno v: The Journal of Experimental Medicine
The A/Japan/57 influenza hemagglutin (HA) peptide HA 128-145, when bound by human histocompatibility leukocyte antigen-DRw11 cells, is recognized by the human CD4+ T cell clone V1. A rabbit antiserum has been raised against HA 128-145 which recognize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a052f2cb13e93a535eb2a281bffa6a0
http://europepmc.org/articles/PMC2118883
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7
The human invariant chain is the core protein of the human class II- associated proteoglycan
Autor: Andrea J. Sant, J Gorka, Vito Quaranta, Chris Bono, D M O'Sullivan, K S Giacoletto, Benjamin D. Schwartz
Publikováno v: The Journal of Experimental Medicine
The human class II-associated chondroitin sulfate proteoglycan (CSPG) was analyzed biochemically and immunologically to determine a possible relationship with the human invariant chain (gamma 1) and its related components. The CSPG was purified by a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e341a50381b1de8c3a8b206fb3a957c
http://europepmc.org/articles/PMC2188463
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8
Human Ia alpha- and beta-chains are sulfated
Autor: A J Sant, M Zacheis, T Rumbarger, K S Giacoletto, B D Schwartz
Publikováno v: The Journal of Immunology. 140:155-160
The human Ia antigens (DR, DQ, and DP), determined by genes with the HLA complex, are heterodimers consisting of a 34,000-Da alpha-chain glycoprotein and a 29,000-Da beta-chain glycoprotein. During the course of studies characterizing a recently desc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfe13cb710c32c953e4027b57b680ece
https://doi.org/10.4049/jimmunol.140.1.155
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9
Analysis of normal human tonsil class II antigen glycosylation by lectin affinity chromatography
Autor: K S Giacoletto, B D Schwartz, M Zacheis
Publikováno v: Journal of Biological Chemistry. 261:17004-17010
Human class II molecules include the HLA-DR, -DQ, and -DP alloantigens. Each class II molecule consists of two glycosylated polypeptide chains, the alpha chain and the beta chain. We have used lectin affinity analysis to investigate the glycosylation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5a37d1cfd2aea4b3a22d1fc44084a53
https://doi.org/10.1016/s0021-9258(19)75991-2
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