Výsledky vyhledávání - "K S, Cathcart"

Reversed-Liquid Phase Chromatographic Determination of Cefpodoxime in Human Plasma

Autor: M. E. Royer, R. C. Steenwyk, J. E. Brewer, K. S. Cathcart

Publikováno v: Journal of Liquid Chromatography. 14:3641-3656

The reversed-phase liquid chromatographic determination of cefpodoxime in human plasma is described. Plasma samples were acidified with 1 mL of phosphoric acid solution containing internal standard, and adsorbed onto a C8 solid phase cassette designe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e445c4c921f933f16cc87c582f16f1e0
https://doi.org/10.1080/01483919108049483

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Determination of Cefpodoxime Levels and Cefpodoxime Stability In Human Urine By Direct Injection HPLC with Column-Switching

Autor: Brian E. Bothwell, S. K. Closson, Paul A. Bombardt, K. S. Cathcart

Publikováno v: Journal of Liquid Chromatography. 14:1729-1746

A semi-automated method providing on-line sample extraction and quantitative analysis for cefpodoxime in human urine, injected directly into the HPLC, is reported. Samples were filtered by the analyst, injected into the HPLC system with an autosample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0379ec2e63c1e0eaada8e929087293f7
https://doi.org/10.1080/01483919108049650

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Disposition of cefmetazole in healthy volunteers and patients with impaired renal function

Autor: H. Ko, K. S. Cathcart, John A. Opsahl, L. S. Olanoff, Gary R. Matzke, C E Halstenson, C. A. I. Hirata, D. R. P. Guay, E. Novak

Publikováno v: Antimicrobial Agents and Chemotherapy. 34:519-523

The disposition of cefmetazole was studied in 25 subjects with various degrees of renal function after a 1,000-mg, constant-rate, 30-min intravenous infusion of cefmetazole sodium. In six subjects with creatinine clearance (CLCR) of greater than 90 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1077567b2550005cef266032b08bd1
https://doi.org/10.1128/aac.34.4.519

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Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients

Autor: J G, Slatter, L J, Schaaf, J P, Sams, K L, Feenstra, M G, Johnson, P A, Bombardt, K S, Cathcart, M T, Verburg, L K, Pearson, L D, Compton, L L, Miller, D S, Baker, C V, Pesheck, R S, Lord

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(4)

This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100 microCi) [(14)C]CPT-11 in eight patients with solid tumors. Mean +/- S.D. recovery of radioactivity in urine and feces was 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a052ff69246a2104d461df4a37672029
https://pubmed.ncbi.nlm.nih.gov/10725311

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Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: I. Single-dose administration

Autor: Joseph C. Fleishaker, G.R. Peters, R. C. Steenwyk, K. S. Cathcart

Publikováno v: Journal of clinical pharmacology. 33(2)

The multiple dose tolerability and pharmacokinetics of tirilazad mesylate, a 21-aminosteroid free radical scavenger, were assessed in 50 healthy male volunteers. Volunteers were randomized to receive intravenous normal saline placebo (n = 10), citrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576dcb905a8b9441ca71081858ba15be
https://pubmed.ncbi.nlm.nih.gov/8382708

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Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination

Autor: H Ko, G R Peters, W J Adams, K S Cathcart, D L Griffith

Sixteen healthy male volunteers participated in a randomized, balanced, three-way crossover study comparing the pharmacokinetics of cefmetazole, cefoxitin, and cefmetazole with probenecid pretreatment. Single 2-g doses of cefmetazole sodium and cefox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d5f131cd856ef8d2759120bb172fd3
https://europepmc.org/articles/PMC171493/

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