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2'-substituted analogs of cocaine: synthesis and dopamine transporter binding potencies

Autor: T F, el-Moselhy, K S, Avor, G P, Basmadjian

Publikováno v: Archiv der Pharmazie. 334(8-9)

A series of 2'-substituted cocaine analogs (4-8) was prepared and evaluated in an in vitro dopamine transporter (DAT) binding assay. Compounds 4-7 were prepared by esterifying the 3 beta-hydroxyl group of ecgonine methyl ester (3) using the appropria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::353a142d09859c4a3b7c9e6d308e11c5
https://pubmed.ncbi.nlm.nih.gov/11688137

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Synthesis and biological evaluation of basic side chain derivatives of Analog II as pure antiestrogens and antitumor agents

Autor: R A, Magarian, K S, Avor, L B, Overacre, J, Kunchandy, T R, Paxton

Publikováno v: Anti-cancer drug design. 10(4)

In an effort to prepare effective non-steroidal antiestrogens without intrinsic estrogenicity and with greater antagonism than those of the triarylethylenes (tamoxifen; TAM) four N-substituted (Z)-1,1-dichloro-2-[4-(2-aminoethoxy)phenyl]-3-phenylcycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19744a8c174be1d7600fa4acd4695254
https://pubmed.ncbi.nlm.nih.gov/7786397

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