Zobrazeno 1 - 10
of 32
pro vyhledávání: '"K Rynkiewicz"'
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
Autor:
Matthew J. Eramo, Helen E. Abud, Lisa M Ooms, Samuel J. Rodgers, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie K. Rynkiewicz, Absorn Sriratana, Georg Ramm, Genevieve Kerr, Catriona McLean, Viola Oorschot, Ralf B. Schittenhelm, Sherene Loi, Andrew M. Ellisdon, Rajendra Gurung, Christina Anne Mitchell, Clare G Fedele, Antonella Papa, Roger J. Daly, Franco Caramia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to P
Autor:
O Wozniak, Ilona Michałowska, K Rynkiewicz, Witold Rużyłło, W Skotarczka, Kamil Zieliński, Marcin Demkow, G.S. Mintz, Lukasz Kalinczuk, K Biernacka
Publikováno v:
European Heart Journal. 42
Introduction Large imaging filed intravascular ultrasound (IVUS) offering superior online tomographic perspective and visual accuracy could guide transcatheter pulmonary valve replacement (TPVR) for right ventricular outflow tract (RVOT) insufficienc
Autor:
Roger L. Williams, Sabine Suire, Oscar Vadas, David Oxley, Jonathan Clark, Karen E. Anderson, Natalie K. Rynkiewicz, Eleftherios Karanasios, Phillip T. Hawkins, Len R. Stephens, Daniel M. Collins
Publikováno v:
Sci Signal
The PI3Kγ isoform is activated by Gi-coupled GPCRs in myeloid cells, but the extent to which the two endogenous complexes of PI3Kγ, p101/p110γ and p84/p110γ, receive direct regulation through Gβγ or indirect regulation through RAS and the suffi
Autor:
W Skotarczak, Kamil Zieliński, Marcin Demkow, K Biernacka, Lukasz Kalinczuk, Gary S. Mintz, K Rynkiewicz, Ilona Michałowska, Witold Rużyłło, M Swierczewski
Publikováno v:
European Heart Journal. 41
Introduction Transcatheter heart valve (THV) deployment can be used to treat right ventricular outflow tract (RVOT) insufficiency. Purpose To study deployment mechanism of a balloon expandable THV (Melody or Edwards SAPIEN [ES] 3) implanted for pulmo
Autor:
Kamil Zieliński, Ilona Michałowska, K Rynkiewicz, Marcin Demkow, Lukasz Kalinczuk, M Swierczewski, K Biernacka, W Ryzyllo, G.S. Mintz, W Skotarczak
Publikováno v:
European Heart Journal. 41
Introduction Transcatheter heart valve (THV) deployment can be used to treat right ventricular outflow tract (RVOT) insufficiency, but it is unknown whether manufacturers' predicted THV dimensions correspond with actualy measured. Purpose To compare
Autor:
Benjamin Grimshaw, Erin Spearing, Delphine Meynard, Luke Bayliss, Audrey Belot, Matthew Wake, Volker Germaschewski, Jemima Paterson, Jonathan Papworth, Igor Theurl, Emily Carter, Anais Palin, Amelie Largounez, Natalie K. Rynkiewicz, Verena Petzer, Alicia Poindron, Robyne Hudson
Publikováno v:
Blood. 134:3532-3532
Beta thalassemia is an inherited hemoglobinopathy caused by a genetic defect in beta-globin gene and characterised by ineffective erythropoiesis, iron overload, splenomegaly and anemia. Excessive EPO production, resulting from the anemia, has a suppr
Autor:
Graham G. Giles, Catriona McLean, Karen Chiam, Natalie K. Rynkiewicz, Lisa G. Horvath, James G. Kench, Lisa M Ooms, Clare G Fedele, Christina Anne Mitchell, Ruta Gupta
Publikováno v:
The Prostate. 75:92-102
BACKGROUND Phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in prostate carcinoma due to the loss of tumor suppressor PTEN, which leads to increased Akt activity. Expression of INPP4B, another negative regulator of the PI3K/Akt pa
Akademický článek
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Autor:
Mark A. Guthridge, Natalie K. Rynkiewicz, Nik Cummings, Sewa Rijal, Anthony T. Papenfuss, Andrew H. Wei, Tse-Chieh Teh, Julie McManus, Nhu-Y N Nguyen, Catriona McLean, Sharon Avery, Lisa M Ooms, Shaun Fleming, Christina Anne Mitchell
Publikováno v:
Blood. 125(18)
Phosphoinositide signaling regulates diverse cellular functions. Phosphoinositide-3 kinase (PI3K) generates PtdIns(3,4,5)P3 and PtdIns(3,4)P2, leading to the activation of proliferative and anti-apoptotic signaling pathways. Termination of phosphoino
Autor:
Natalie K, Rynkiewicz, Clare G, Fedele, Karen, Chiam, Ruta, Gupta, James G, Kench, Lisa M, Ooms, Catriona A, McLean, Graham G, Giles, Lisa G, Horvath, Christina A, Mitchell
Publikováno v:
The Prostate. 75(1)
Phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in prostate carcinoma due to the loss of tumor suppressor PTEN, which leads to increased Akt activity. Expression of INPP4B, another negative regulator of the PI3K/Akt pathway, is a