Zobrazeno 1 - 10
of 37
pro vyhledávání: '"K R McLeish"'
Autor:
Carl D. Langefeld, Gary S. Gilkeson, John B. Harley, Ryan M. Sheehan, Chaim O. Jacob, Susan A. Boackle, Timothy B. Niewold, Anne M. Stevens, John D. Reveille, Betty P. Tsao, Jeffrey C. Edberg, Rachel T. G'Sell, Erik A. Korte, Barry I. Freedman, K R McLeish, Rebecca K. Oliver, Darrell W. Freeman, Judith A. James, Juan-Manuel Anaya, Diane L. Kamen, Marta E. Alarcón-Riquelme, Susan Coventry, Patrick M. Gaffney, Lindsey A. Criswell, Indra Adrianto, Rosalind Ramsey-Goldman, Sang Cheol Bae, Bernardo A. Pons-Estel, Dawn J. Caster, Jennifer A. Kelly, Michelle Petri, Sambit K. Nanda, Javier Martin, David W. Powell, Kenneth M. Kaufman, Joel M. Guthridge, Kathy L. Sivils, Robert P. Kimberly, Elizabeth E. Brown, Luis M. Vilá, Graciela S. Alarcón, Timothy J. Vyse, Joan T. Merrill, R. Hal Scofield, Philip Cohen
Publikováno v:
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Europe PubMed Central
Universidad del Rosario
instacron:Universidad del Rosario
Europe PubMed Central
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-?B is involved. We reported previously that aknockin mouse
Autor:
Michelle T. Barati, William M. Nauseef, Greg Luerman, K R McLeish, Richard A. Ward, Madhavi J. Rane, Silvia M. Uriarte
Publikováno v:
The Journal of Immunology. 187:391-400
The role of exocytosis in the human neutrophil respiratory burst was determined using a fusion protein (TAT–SNAP-23) containing the HIV transactivator of transcription (TAT) cell-penetrating sequence and the N-terminal SNARE domain of synaptosome-a
Autor:
David W. Powell, Richard A. Ward, Greg C. Luerman, K R McLeish, George Lominadze, Andrew J. Link
Publikováno v:
Molecular & Cellular Proteomics. 4:1503-1521
Stimulated exocytosis of intracellular granules plays a critical role in conversion of inactive, circulating neutrophils to fully activated cells capable of chemotaxis, phagocytosis, and bacterial killing. The functional changes induced by exocytosis
Publikováno v:
The Journal of Immunology. 158:913-918
Priming of polymorphonuclear leukocyte responses to chemoattractants by TNF plays an important role in host defenses and inflammatory responses. TNF-induced priming is associated with an 80% increase in the membrane density of G alpha(i2) protein tha
Autor:
D. Goldwater, Gerald Sonnenfeld, K R McLeish, D A Koebel, E. S. Miller, Jon B. Klein, Stephanie Davis
Publikováno v:
Journal of Applied Physiology. 76:387-390
The influence of spaceflight on the oxidative burst of neutrophils is not known. The present study was designed to evaluate the influence of antiorthostatic suspension, a ground-based modeling system designed to simulate certain aspects of weightless
Publikováno v:
The Journal of Immunology. 150:1913-1921
The ability of HL-60 cells differentiated with DMSO or retinoic acid (RA) to serve as models for polymorphonuclear leukocytes was examined. NaF and FMLP stimulated superoxide release from both groups of cells, but the response was attenuated in RA-di
Publikováno v:
The Journal of Immunology. 148:2483-2488
Exposure to IFN-gamma increases the respiratory burst of polymorphonuclear leukocytes stimulated by the chemoattractant FMLP. However, the mechanism by which IFN-gamma alters the response to FMLP is unclear. We addressed the hypothesis that IFN-gamma
Publikováno v:
The Journal of Immunology. 144:4305-4311
IFN-gamma enhances many monocyte functions, including oxidative metabolism and Ag presentation. IFN-gamma has been reported to increase the intracellular concentration of calcium ([Ca2+]i) and modulate protein kinase C activity in murine macrophages,
Publikováno v:
Journal of leukocyte biology. 64(6)
The hypothesis that bacterial phagocytosis by human polymorphonuclear neutrophils (PMNs) stimulates MAPK cascades that regulate respiratory burst activation was tested. Extracellular response kinase (ERK) and p38 kinase, but not c-Jun NH2-terminal ki
Publikováno v:
Journal of leukocyte biology. 64(4)
The signal transduction pathways activated by tumor necrosis factor alpha (TNF-alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) that lead to priming of polymorphonuclear leukocytes (PMNs) are unknown. The hypotheses that these cyt