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POS1428 IDENTIFICATION OF A WARM AUTOIMMUNE HEMOLYTIC ANEMIA (wAIHA) POPULATION USING PREDICTIVE ANALYTICS OF A KNOWN CLINICALLY PROFILED COHORT

Autor: K. R. Mccrae, T. Gooljarsingh, G. K. Jones, M. L. Tjoa

Publikováno v: Annals of the Rheumatic Diseases. 81:1057.1-1057

BackgroundThe disease burden of warm autoimmune hemolytic anemia (wAIHA), a rare disorder characterized by the destruction of red blood cells (RBCs) by pathogenic IgG autoantibodies, has not been well studied. At the time this claims database analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f85544cc7771e5d9bd99d234891c783
https://doi.org/10.1136/annrheumdis-2022-eular.2607

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Pregnancy-associated thrombocytopenia: pathogenesis and management

Autor: K R, McCrae, P, Samuels, A D, Schreiber

Publikováno v: Blood. 80:2697-2714

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171259108995234db8db379f9487479f
https://doi.org/10.1182/blood.v80.11.2697.2697

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Characterization of urokinase receptor expression by human placental trophoblasts

Autor: J M, Zini, S C, Murray, C H, Graham, P K, Lala, K, Karikó, E S, Barnathan, A, Mazar, J, Henkin, D B, Cines, K R, McCrae

Publikováno v: Blood. 79:2917-2929

The processes of implantation and placentation are both dependent on the invasion and remodeling of the uterine endometrium and vasculature by trophoblasts. Because the secretion and autocrine binding of urokinase (uPA) appears to be a common mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cb547a91eb0a19fbbaed6184d158b7
https://doi.org/10.1182/blood.v79.11.2917.bloodjournal79112917

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Platelet activation induces increased Fc gamma receptor expression

Autor: K R McCrae, S J Shattil, D B Cines

Publikováno v: The Journal of Immunology. 144:3920-3927

Platelet contain Fc gamma RII. However, little is known about how the expression of these receptors is regulated. Inasmuch as platelet activation by a variety of agonists increases the expression of several proteins on the platelet surface, we used f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e6ae321d2f3732b62ea719c78033327
https://doi.org/10.4049/jimmunol.144.10.3920

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Persistant pre-eclampsia post partum with elevated liver enzymes and hemolytic uremic syndrome

Autor: K, Mahalati, R B, Dawson, J O, Collins, W R, Bell, K R, McCrae, J N, Martin

Publikováno v: Journal of clinical apheresis. 14(2)

The spectrum of complications with pre-eclampsia, which may include AFLP (acute fatty liver of pregnancy) as well as the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), is resolved by early delivery. However, the ravages of HUS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fdab0b74188c26d5a561c8600ced767
https://pubmed.ncbi.nlm.nih.gov/10440942

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SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta

Autor: N K, Khoo, J F, Bechberger, T, Shepherd, S L, Bond, K R, McCrae, G S, Hamilton, P K, Lala

Publikováno v: International journal of cancer. 77(3)

Invasion of the uterus by first trimester human placental extravillous trophoblast (EVT) cells depends on mechanisms shared by malignant cells. However, unlike tumor invasion, trophoblast invasion of the uterus is stringently controlled in situ by lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e9b90def64cb95bb13827f0367d26ef
https://pubmed.ncbi.nlm.nih.gov/9663607

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Endothelial cells in physiology and in the pathophysiology of vascular disorders

Autor: D B, Cines, E S, Pollak, C A, Buck, J, Loscalzo, G A, Zimmerman, R P, McEver, J S, Pober, T M, Wick, B A, Konkle, B S, Schwartz, E S, Barnathan, K R, McCrae, B A, Hug, A M, Schmidt, D M, Stern

Publikováno v: Blood. 91(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1fe3680d7104698bd3368ac171e260d7
https://pubmed.ncbi.nlm.nih.gov/9572988

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Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway

Autor: C H, Graham, T E, Fitzpatrick, K R, McCrae

Publikováno v: Blood. 91(9)

Hypoxia underlies a number of biologic processes in which cellular migration and invasion occur. Because earlier studies have shown that the receptor for urokinase-type plasminogen activator (uPAR) may facilitate such events, we studied the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43e2f61c413871b5569dcc1d339d9f5b
https://pubmed.ncbi.nlm.nih.gov/9558386

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