Zobrazeno 1 - 10 of 11 pro vyhledávání: '"K R Bales"'
1
Apolipoprotein E, Amyloid, and Alzheimer Disease
Autor: Ronald B. DeMattos, K R Bales, David M. Holtzman, Steven M. Paul, Jean Cosme Dodart
Publikováno v: Molecular Interventions. 2:363-375
Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616840729d257edd4076560776e07cec
https://doi.org/10.1124/mi.2.6.363
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3
Does my mouse have Alzheimer's disease?
Autor: J C, Dodart, C, Mathis, K R, Bales, S M, Paul
Publikováno v: Genes, brain, and behavior. 1(3)
Small animal models that manifest many of the characteristic neuropathological and behavioral features of Alzheimer's disease (AD) have been developed and have proven of great value for studying the pathogenesis of this disorder at the molecular, cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84b76dcd11433c520629438d0b4bc501
https://pubmed.ncbi.nlm.nih.gov/12884970
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4
Modulation of A beta deposition in APP transgenic mice by an apolipoprotein E null background
Autor: Michael C. Irizarry, G.W. Rebeck, Steven M. Paul, B. T. Hyman, K R Bales, Bonnie S. Cheung, D. Holzman
Publikováno v: Annals of the New York Academy of Sciences. 920
Several lines of evidence implicate apolipoprotein E (apoE) and its receptor--the low density lipoprotein receptor related protein (LRP)--in Alzheimer's disease (AD) pathogenesis, including increased amyloid deposition in human AD brains of people co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cddaf8874049159399dd066f561cbc
https://pubmed.ncbi.nlm.nih.gov/11193147
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5
Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice
Autor: B. T. Hyman, Michael C. Irizarry, K R Bales, S M Paul, G W Rebeck, Bonnie S. Cheung
Publikováno v: Acta neuropathologica. 100(5)
Apolipoprotein E (apoE) has been implicated as a risk factor for Alzheimer's disease and in the deposition, fibrillogenesis, and clearance of the amyloid beta-peptide (Abeta). To examine the in vivo interactions between apoE and Abeta deposition, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdff3cd428b4e33c24b731f3db82e9fa
https://pubmed.ncbi.nlm.nih.gov/11045665
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6
Alpha2 macroglobulin and the risk of Alzheimer's disease
Autor: R C, Dodel, Y, Du, K R, Bales, F, Gao, B, Eastwood, B, Glazier, R, Zimmer, B, Cordell, A, Hake, R, Evans, D, Gallagher-Thompson, L W, Thompson, J R, Tinklenberg, A, Pfefferbaum, E V, Sullivan, J, Yesavage, L, Alstiel, T, Gasser, M R, Farlow, G M, Murphy, S M, Paul
Publikováno v: Neurology. 54(2)
alpha2 Macroglobulin is a panproteinase inhibitor that is found immunohistochemically in neuritic plaques, a requisite neuropathologic feature of AD. Recently, a pentanucleotide deletion near the 5' end of the "bait region" of the alpha2 macroglobuli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0dfa8201dde0e490d807ffa91c681fc6
https://pubmed.ncbi.nlm.nih.gov/10668709
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7
Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
Autor: J C, Dodart, H, Meziane, C, Mathis, K R, Bales, S M, Paul, A, Ungerer
Publikováno v: Behavioral neuroscience. 113(5)
PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62e1e9089c9930798f8217175b55d742
https://pubmed.ncbi.nlm.nih.gov/10571480
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8
Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795
Autor: A E, Kingston, M J, O'Neill, A, Lam, K R, Bales, J A, Monn, D D, Schoepp
Publikováno v: European journal of pharmacology. 377(2-3)
In rat cortical neuronal cultures, metabotropic glutamate (mGlu) receptor agonists: LY354740 (+)-2-aminobicyclo[3.1.0]hexane-2,6dicarboxylate); LY379268 (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate, and LY389795 (-)-2-thia-4-aminobicyclo[3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d6274eaf12eb5e5cd18f9ece0338af6
https://pubmed.ncbi.nlm.nih.gov/10456425
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10
Peptide inhibitors of caspase-3-like proteases attenuate 1-methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons
Autor: R C, Dodel, Y, Du, K R, Bales, Z D, Ling, P M, Carvey, S M, Paul
Publikováno v: Neuroscience. 86(3)
Multiple aspartate-specific cysteine proteases have been identified and specific members of this family have been implicated in the apoptotic death of many mammalian cell types. Caspase-3-like proteases seem to play a pivotal role in neuronal apoptos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::049e06302ec550ff67aac1dbf37fced9
https://pubmed.ncbi.nlm.nih.gov/9692710
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