Zobrazeno 1 - 10 of 17 pro vyhledávání: '"K R, Wilske"'
1
VH usage and somatic hypermutation in peripheral blood B cells of patients with rheumatoid arthritis (RA)
Autor: Eric C. B. Milner, S.-C. Huang, Daniel E. Furst, K. R. Wilske, R. Jiang, W. O. Hufnagle
Publikováno v: Clinical and Experimental Immunology. 112:516-527
SUMMARYThe human antibody repertoire has been demonstrated to have a marked V-gene-dependent bias that is conserved between individuals. In RA patients, certain heavy chain V genes (VH) have been found to be preferentially used for encoding autoantib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef062ea9be9a37ac9f1de2461a9677e
https://doi.org/10.1046/j.1365-2249.1998.00580.x
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4
Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar
Autor: R K, Vehe, G T, Nepom, K R, Wilske, D, Stage, A B, Begovich, B S, Nepom
Publikováno v: The Journal of rheumatology. 21(2)
The relationship between rheumatoid factor positive (RF+) and rheumatoid factor negative (RF-) rheumatoid arthritis (RA) is controversial. We sought to determine whether the HLA genes conferring susceptibility for erosive RF+RA are also prevalent in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebcb20b747455103fdcf6ad9cd3c6d2d
https://pubmed.ncbi.nlm.nih.gov/8182623
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5
Approaches to the management of rheumatoid arthritis: rationale for early combination therapy
Autor: K R, Wilske
Publikováno v: British journal of rheumatology. 32
In evaluating current therapy of RA, it is becoming recognized that sequential single drug treatment, as exemplified by the traditional therapeutic pyramid, is often too little and too late in patients with aggressive 'at risk' synovitis. Evidence ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15fc71b8ada42d4bbda7e24971be9878
https://pubmed.ncbi.nlm.nih.gov/8448633
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6
The need for aggressive therapy of rheumatoid arthritis
Autor: K R, Wilske, L A, Healey
Publikováno v: Rheumatic diseases clinics of North America. 19(1)
We are on the threshold of a new era in the treatment of RA if we learn from the experience of the past and utilize new techniques and therapeutic modalities that the future will bring. New strategies and treatment of RA in the future will need to in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6449ecbd69b3046f49eafe1d23e47d0
https://pubmed.ncbi.nlm.nih.gov/8356250
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8
Challenging the therapeutic pyramid: a new look at treatment strategies for rheumatoid arthritis
Autor: K R, Wilske, L A, Healey
Publikováno v: The Journal of rheumatology. Supplement. 25
Traditional therapy of rheumatoid arthritis (RA) has been dominated by the therapeutic pyramid. This approach is not working. The designation of drugs as either antiinflammatory or disease modifying is not borne out by experience. We possess a number
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::660f67828220ee47d7285bf9047afb64
https://pubmed.ncbi.nlm.nih.gov/2273521
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