Zobrazeno 1 - 7
of 7
pro vyhledávání: '"K R, Sweeney"'
Publikováno v:
Drug discoveriestherapeutics. 4(1)
The objective of this analysis was to explore exposure-response modeling of data from a thorough QT (TQT) study of tolterodine in CYP2D6 extensive (EMs) and poor metabolizers (PMs). Crossover treatments of the TQT study included the recommended (2 mg
Publikováno v:
Handchirurgie Scan. :282-282
Publikováno v:
Antimicrobial Agents and Chemotherapy. 35:384-386
The pharmacokinetics and bioavailability of ofloxacin in 20 healthy male volunteers were studied in an open-label, randomized, two-way crossover study. Ofloxacin (400 mg) was administered either as a 1-h infusion or as an oral tablet. The mean peak c
Publikováno v:
Pharmaceutical research. 12(12)
Dideoxynucleoside bases are used for the treatment of acquired immune deficiency syndrome (AIDS), acting by inhibiting reverse transcriptase and preventing human immunodeficiency virus (HIV) replication. Currently, AZT (zidovudine), ddC (zalcitibine)
Publikováno v:
Pharmacotherapy. 15(4)
To compare the pharmacokinetic and pharmacodynamic activity of three drug regimens: cefotaxime plus metronidazole, cefoxitin, and ampicillin-sulbactam against two organisms frequently isolated in intraabdominal infection, Escherichia coli and Bactero
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(3)
The mechanism of methotrexate (MTX) renal elimination and the interaction of MTX with the nonsteroidal anti-inflammatory drugs, indomethacin and flurbiprofen, were characterized in the isolated perfused rat kidney. Perfusion studies elucidating MTX r
Publikováno v:
Annals of clinical and laboratory science. 20(6)
The feasibility of monitoring cisplatin chemotherapy by measuring platinum (Pt) concentrations in blood mononuclear cells was tested in six patients (four with squamous cell carcinomas of the head and neck, one with non-Hodgkin's lymphoma, and one wi