Výsledky vyhledávání - "K R, Marotti"

Cholesteryl ester transfer protein's role in high-density lipoprotein metabolism Insights from studies with transgenic mice

Autor: G W, Melchior, K R, Marotti

Publikováno v: Trends in cardiovascular medicine. 5(3)

A substantial percentage of people who develop coronary artery atherosclerosis have plasma cholesterol levels in the "desirable" range. The principal lipid abnormality in most of these individuals is a low plasma high-density lipoprotein (HDL) level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f7c5938302dcf497669e3dd162d9228
https://pubmed.ncbi.nlm.nih.gov/21232242

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Co-expression of cholesteryl ester transfer protein and defective apolipoprotein E in transgenic mice alters plasma cholesterol distribution. Implications for the pathogenesis of type III hyperlipoproteinemia

Autor: S, Fazio, K R, Marotti, Y L, Lee, C K, Castle, G W, Melchior, S C, Rall

Publikováno v: The Journal of biological chemistry. 269(51)

Despite the definite etiologic link between apolipoprotein (apo) E mutations and type III hyperlipoproteinemia (HLP), it is not clear what additional factors are involved in the development of florid hyperlipidemia and how to explain the wide variabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8416e5b5b0663a08a4091b1baa92328
https://pubmed.ncbi.nlm.nih.gov/7798236

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Apolipoprotein A-I metabolism in cholesteryl ester transfer protein transgenic mice. Insights into the mechanisms responsible for low plasma high density lipoprotein levels

Autor: G W, Melchior, C K, Castle, R W, Murray, W L, Blake, D M, Dinh, K R, Marotti

Publikováno v: The Journal of biological chemistry. 269(11)

Expression of simian cholesteryl ester transfer protein (CETP) in C57BL/6 mice causes the animals' high density lipoprotein (HDL) levels to decrease. The purpose of these studies was to determine how CETP expression caused that reduction. Chemical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::964cb84de94a6977a29642bb45781fe0
https://pubmed.ncbi.nlm.nih.gov/8132527

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Introduction of lysine and clot binding properties in the kringle one domain of tissue-type plasminogen activator

Autor: A H, Bakker, W, van der Greef, E F, Rehberg, K R, Marotti, J H, Verheijen

Publikováno v: The Journal of biological chemistry. 268(25)

Despite the high overall similarity in primary structure between kringle one (K1) and kringle two (K2) of tissue-type plasminogen activator (t-PA) there exists an enormous functional difference. It is thought that, in contrast to K1, K2 mediates lysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88141e751d7aed97697001b63d5a714d
https://pubmed.ncbi.nlm.nih.gov/8395505

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Structure of the murine gene encoding apolipoprotein A-I

Autor: T P, Boyle, K R, Marotti

Publikováno v: Gene. 117(2)

A 1.6-kb DNA fragment containing the gene encoding apolipoprotein A-I from the mouse, Mus musculus, has been cloned and sequenced. It contains three exons separated by two introns and encodes a secreted polypeptide of 262 amino acids (aa), 238 of whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd9f172e8b6c52c255c2267f68a266b3
https://pubmed.ncbi.nlm.nih.gov/1639271

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Evidence that the nonparenchymal cells of the liver are the principal source of cholesteryl ester transfer protein in primates

Autor: M E, Pape, R G, Ulrich, T J, Rea, K R, Marotti, G W, Melchior

Publikováno v: The Journal of biological chemistry. 266(20)

Previous studies showed that 90% or more of the cholesteryl ester transfer protein (CETP) mRNA is contained in the liver of cynomolgus monkeys. The purpose of this study was to determine if the parenchymal cells (hepatocytes) were the hepatic cell ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5371eec89b8005933589cb47a4b6c3ec
https://pubmed.ncbi.nlm.nih.gov/1906459

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Design of novel thrombolytic agents via domain modifications

Autor: L A, Erickson, K R, Marotti

Publikováno v: Toxicologic pathology. 18(4 Pt 1)

Generation of plasmin in the vicinity of a blood clot has proven to be an effective approach for treating thrombotic disorders, particularly myocardial infarction. Conceptually, the ideal thrombolytic agent would initiate the formation of plasmin, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f7bfb3f4a9d0443b11b3efb63ac5305
https://pubmed.ncbi.nlm.nih.gov/2128661

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