Zobrazeno 1 - 10
of 11
pro vyhledávání: '"K R, Gans"'
Autor:
I. Delucca, Janet S. Kerr, B. Jaffee, Wendell Wilkie Wilkerson, K R Gans, R. R. Harris, W. Galbraith
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa5c616973a8c5f502a6fa7180a0115
https://doi.org/10.1002/chin.199206254
https://doi.org/10.1002/chin.199206254
Autor:
Wendell Wilkie Wilkerson, B. Jaffee, W. Galbraith, I. Delucca, R Harris, K R Gans, Janet S. Kerr
Publikováno v:
European Journal of Medicinal Chemistry. 26:667-676
A novel series of dehydroabietylamine derivatives has been synthesized and shown to be inhibitors of phospholipase-A 2 (PLA 2 ). These compounds exhibit in vivo antiinflammatory activity in the rat carrageenan paw edema assay and support the concept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bebe442736ba3be0501f0eac457c0566
https://doi.org/10.1016/0223-5234(91)90116-5
https://doi.org/10.1016/0223-5234(91)90116-5
Publikováno v:
The Journal of Immunology. 144:2671-2677
Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06f1c877e67f72bbadb0c07f2444437
https://doi.org/10.4049/jimmunol.144.7.2671
https://doi.org/10.4049/jimmunol.144.7.2671
Autor:
K R, Gans, W, Galbraith, R J, Roman, S B, Haber, J S, Kerr, W K, Schmidt, C, Smith, W E, Hewes, N R, Ackerman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(1)
DuP 697 (5-bromo-2[4-fluorophenyl]-3-[4-methylsulfonylphenyl]-thiophene) is a potent inhibitor of paw swelling in nonestablished and established adjuvant arthritis in rats (ED50 = 0.03 and 0.18 mg/kg/day, respectively). DuP 697 had no effect on pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3a1b76baf1ab2f405b8705363da0b67
https://pubmed.ncbi.nlm.nih.gov/2366180
https://pubmed.ncbi.nlm.nih.gov/2366180
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 144(7)
Intraperitoneal injection of zymosan into mice induces a peritonitis characterized by cellular influx, plasma leakage and the appearance of arachidonic acid (AA) metabolites. We report that zymosan injection also stimulates the accumulation of AA, do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13fd1304f29f9a35ee7925bc404529df
https://pubmed.ncbi.nlm.nih.gov/2108209
https://pubmed.ncbi.nlm.nih.gov/2108209
Publikováno v:
Advances in experimental medicine and biology. 275
Two "in vivo" models of inflammation have been used to investigate the role of phospholipases A2 (PLA2) in inflammation. These models are casein-induced peritonitis in the rat and zymosan-induced peritonitis in the mouse. The extracellular PLA2 activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da12bb4509d474068c00c0259ac708e2
https://pubmed.ncbi.nlm.nih.gov/2122642
https://pubmed.ncbi.nlm.nih.gov/2122642
Autor:
N. Cannon, C. Smith, L.C. Johnson, R.C. Newton, R. L. Dowling, S. R. Lundy, N.R. Ackernan, K R Gans
Publikováno v:
European Journal of Pharmacology. 183:2282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44bdf99de28ee873740ccf6ab9def688
https://doi.org/10.1016/0014-2999(90)93830-j
https://doi.org/10.1016/0014-2999(90)93830-j
Publikováno v:
Biochemical Pharmacology. 38:4151-4154
Intrapleural injection of sodium arachidonate to rats produced both a cellular response and the generation of hydroxy fatty acid metabolites of arachidonic acid without edema. The cellular influx was inhibited by mixed 5-lipoxygenase/cyclooxygenase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b72a17d06289d58755cfffdc9420c9
https://doi.org/10.1016/0006-2952(89)90698-9
https://doi.org/10.1016/0006-2952(89)90698-9
Publikováno v:
Arthritis and rheumatism. 23(6)
A radioisotopic method, originally developed for measuring the cellular response in delayed hypersensitivity lesions in mice, has been evaluated in adjuvant arthritic rats. Focal accumulation of 5-iodo-2'-deoxyuridine-125I (125IUdR) at a site of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896451c1d0b2fd3764840603f6b68546
https://pubmed.ncbi.nlm.nih.gov/7387739
https://pubmed.ncbi.nlm.nih.gov/7387739
Publikováno v:
Agents and actions. 27(3-4)
The kinetics and appearance of extracellular phospholipase A2 (PLA2) activity and its relationship to the appearance of arachidonic acid (AA) metabolites in the peritoneal cavity of mice injected with zymosan is described. AA metabolites levels inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9149ed9f705f95bb0fa42fc454f37ede
https://pubmed.ncbi.nlm.nih.gov/2508443
https://pubmed.ncbi.nlm.nih.gov/2508443