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pro vyhledávání: '"K R, Chien"'
Autor:
K R, Chien
Publikováno v:
Trends in cardiovascular medicine. 6(1)
Publikováno v:
The Journal of Immunology. 144:3506-3512
Bacterial LPS and TNF induce vascular endothelial cells to express a variety of response molecules. LPS that is partially deacylated (dLPS) by a human neutrophil enzyme blocks the ability of LPS, but not TNF, to augment one of these responses, the ex
Publikováno v:
Revista espanola de cardiologia. 54(12)
The past three years can be considered in cardiology as critical for understanding the relevance of developmental genes in the adult cardiac physiology. Also, for the first time, endogenous control of programmed cell death has been demonstrated to ma
Autor:
K R, Chien
Publikováno v:
Seminars in oncology. 27(6 Suppl 11)
Recent clinical studies have documented the efficacy of trastuzumab (Herceptin; Genentech, Inc, South San Francisco, CA) as a new biologically targeted therapy for erbB-2 receptor-positive forms of breast cancer. During the course of a large-scale cl
Publikováno v:
The Journal of biological chemistry. 273(13)
The assembly of contractile proteins into organized sarcomeric units is one of the most distinctive features of cardiac myocyte hypertrophy. In a well characterized in vitro model system using cultured neonatal rat ventricular myocytes, a subset of G
Autor:
M, Pashmforoush, K R, Chien
Publikováno v:
Circulation. 96(12)
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 208(4)
We have isolated the mouse homologue of human spliceosome-associated protein SAP49, mSAP49. mSAP49 contains two RNA recognition motifs (RRM) in the N terminus of the predicted amino acid sequence, and a highly basic C terminus rich in glycine/proline
Publikováno v:
The Journal of biological chemistry. 272(9)
Cardiac myocyte survival is of central importance in the maintenance of the function of heart, as well as in the development of a variety of cardiac diseases. To understand the molecular mechanisms that govern this function, we characterized apoptosi
Publikováno v:
The Journal of biological chemistry. 271(49)
G protein-coupled receptor agonists initiate a cascade of signaling events in neonatal rat ventricular myocytes that culminates in changes in gene expression and cell growth characteristic of hypertrophy. These responses have been previously shown to
Autor:
K C, Wollert, T, Taga, M, Saito, M, Narazaki, T, Kishimoto, C C, Glembotski, A B, Vernallis, J K, Heath, D, Pennica, W I, Wood, K R, Chien
Publikováno v:
The Journal of biological chemistry. 271(16)
Cardiotrophin-1 (CT-1) was recently isolated by expression cloning based on its ability to induce an increase in cell size in neonatal rat ventricular cardiomyocytes. Sequence similarity data suggested that CT-1 is a novel member of a family of struc