Zobrazeno 1 - 10
of 48
pro vyhledávání: '"K R, Acharya"'
Autor:
K. R. Acharya, Anastassios C. Papageorgiou, Stephen H. Prior, Darrell Sleep, E Mitsiki, Nethaji Thiyagarajan, Shalini Iyer, C Finnis
Publikováno v:
Biochemical and Biophysical Research Communications
Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc653531b89fd2d5da2224c691d8842
https://doi.org/10.1016/j.bbrc.2009.06.104
https://doi.org/10.1016/j.bbrc.2009.06.104
Publikováno v:
Protein Science. 9:610-618
Staphylococcal aureus epidermolytic toxins (ETs) A and B are responsible for the induction of staphylococcal scalded skin syndrome, a disease of neonates and young children. The clinical features of this syndrome vary from localized blisters to sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963b72645270a263dfd16830b028c189
https://doi.org/10.1110/ps.9.3.610
https://doi.org/10.1110/ps.9.3.610
Autor:
Marieke Guy, K. R. Acharya, Bradley R. Kelemen, Cara L. Jenkins, Ronald T. Raines, Rozamond Y. Sweeney, Nethaji Thiyagarajan
Publikováno v:
FEBS Journal. 272:744-755
2'-Fluoro-2'-deoxyuridine 3'-phosphate (dU(F)MP) and arabinouridine 3'-phosphate (araUMP) have non-natural furanose rings. dU(F)MP and araUMP were prepared by chemical synthesis and found to have three- to sevenfold higher affinity than uridine 3'-ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b7528f783cc08e821574b39b991c34
https://doi.org/10.1111/j.1742-4658.2004.04511.x
https://doi.org/10.1111/j.1742-4658.2004.04511.x
Publikováno v:
Biochemistry. 42:1451-1459
RNase inhibitor (RI) binds diverse proteins in the pancreatic RNase superfamily with extremely high avidity. Previous studies showed that tight binding of RNase A and angiogenin (Ang) is achieved primarily through interactions of hot spot residues in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8bb5a0c4111444bc2356c411c102b8
https://doi.org/10.1021/bi026852o
https://doi.org/10.1021/bi026852o
Autor:
Nikos G. Oikonomakos, K. R. Acharya, Socrates J. Tzartos, Demetres D. Leonidas, Efstratia H. Vatzaki, Panayota Tsantili, M. Kontou, Avgi Mamalaki
Publikováno v:
European Journal of Biochemistry. 267:2389-2397
The crystal structure of the Fab fragment of a rat monoclonal antibody, number 192, with a very high affinity (Kd = 0.05 nm) for the main immunogenic region of the human muscle acetylcholine receptor (AChR), has been determined and refined to 2.4 A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ef406a4a6108bc7bb3f8a3199afab4
https://doi.org/10.1046/j.1432-1327.2000.01252.x
https://doi.org/10.1046/j.1432-1327.2000.01252.x
Publikováno v:
The EMBO Journal. 16:5162-5177
Human placental RNase inhibitor (hRI), a leucine-rich repeat protein, binds the blood vessel-inducing protein human angiogenin (Ang) with extraordinary affinity (Ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9cb522021d422bb5359ed362bf067e4
https://doi.org/10.1093/emboj/16.17.5162
https://doi.org/10.1093/emboj/16.17.5162
Autor:
Spyros E. Zographos, K. R. Acharya, Katerina E. Tsitsanou, Louise N. Johnson, N.G. Oikonomakos
Publikováno v:
Protein Science. 5:2416-2428
It has been established that phosphate analogues can activate glycogen phosphorylase reconstituted with pyridoxal in place of the natural cofactor pyridoxal 5'-phosphate (Change YC. McCalmont T, Graves DJ. 1983. Biochemistry 22:4987-4993). Pyridoxal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903b4ed6a66d046c1d83c58b7809a106
https://doi.org/10.1002/pro.5560051204
https://doi.org/10.1002/pro.5560051204
Autor:
Anastassios C. Papageorgiou, Rossalyn D. Brehm, C. P. Quinn, K. R. Acharya, Howard S. Tranter, P. F. Bonventre, D. Beer
Publikováno v:
Protein Science. 5:1737-1741
Toxic shock syndrome toxin-1 (TSST-1) is one of a family of staphylococcal exotoxins recognized as microbial superantigens. The toxin plays a dominant role in the genesis of toxic shock in humans through a massive activation of the immune system. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76280bd112feda68c72320c6633a8eb
https://doi.org/10.1002/pro.5560050826
https://doi.org/10.1002/pro.5560050826
Autor:
K. R. Acharya, Rossalyn D. Brehm, Demetres D. Leonidas, Anastassios C. Papageorgiou, Howard S. Tranter
Publikováno v:
Journal of Molecular Biology. 260:553-569
The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus is a causative agent of the toxic shock syndrome disease. It belongs to a family of proteins known as superantigens that cross-link major histocompatibility class II molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fe89337319e11270a14cb43c77fec7
https://doi.org/10.1006/jmbi.1996.0421
https://doi.org/10.1006/jmbi.1996.0421
Publikováno v:
Proceedings of the National Academy of Sciences. 91:2915-2919
Angiogenin, a potent inducer of neovascularization, is the only angiogenic molecule known to exhibit ribonucleolytic activity. Its overall structure, as determined at 2.4 A, is similar to that of pancreatic ribonuclease A, but it differs markedly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a0916d03ea188321e6d73186264439
https://doi.org/10.1073/pnas.91.8.2915
https://doi.org/10.1073/pnas.91.8.2915