Výsledky vyhledávání

Application of fine-needle aspiration to the demonstration of ERBB2 and MYC expression by in situ hybridization in breast carcinoma

Autor: Paavo Pääkkö, H. Kiviniemi, K Poikonen, Ylermi Soini, Dia Kamel, R Winqvist, A Mannermaa

Publikováno v: Journal of Histochemistry & Cytochemistry. 42:795-803

Thirteen consecutive fine-needle aspirates of breast carcinoma and five selected breast tumor cell lines were analyzed for ERBB2 and MYC mRNA expression by in situ hybridization. To compare the level of mRNA synthesis with those of gene amplification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9b394f63015a90d8e8119981d80fd4
https://doi.org/10.1177/42.6.7910618

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Helicobacter pylori induces lymphocyte activation in peripheral blood cultures

Autor: G. Andersson, K Poikonen, Riitta Karttunen, Seppo Niemelä, T U Kosunen, K Juutinen, Tuomo J. Karttunen

Publikováno v: Scopus-Elsevier

Summary Helicobacter pylori-induced, in vitro stimulation of mononuclear cells was characterized by measuring DNA synthesis response, interferon-gamma (IFN-γ) secretion and the number of immunoglobulin-secreting cells. The strength of these response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c030a81f0c707baef863ec3b1382475b
https://doi.org/10.1111/j.1365-2249.1990.tb05476.x

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SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef

Autor: M, Hiipakka, K, Poikonen, K, Saksela

Publikováno v: Journal of molecular biology. 293(5)

The avid binding of HIV-1 Nef to the Src homology-3 (SH3) domain of Hck (KD 250 nM) has been shown to involve an interaction between the RT-loop of Hck-SH3 and residues in Nef outside of its prototypic polyproline type II (PPII) helix-containing SH3-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27e87961d803bca3722db0d53af63775
https://pubmed.ncbi.nlm.nih.gov/10547288

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T-cell subpopulations in the cerebrospinal fluid and peripheral blood of patients with multiple sclerosis: a follow-up study

Autor: S. Tarvonen, O. Oksaranta, Mauri Reunanen, R. Salonen, M. Panelius, J. Ilonen, K. Poikonen

Publikováno v: Neurology. 47(6)

We analyzed the relative and absolute numbers of CD4+ cells positive and negative for CD45RA marker as well as the numbers of CD8+ cells positive and negative for CD11b in the cerebrospinal fluid (CSF) and peripheral blood (PB) of 17 patients with mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3573ba1379a549b84888e87b2b8550
https://pubmed.ncbi.nlm.nih.gov/8960742

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Analysis of impaired in vitro immunoglobulin synthesis in rheumatoid arthritis

Autor: K Poikonen, H M Surcel, Timo Möttönen, Martti Oka, Karttunen R, H Arvilommi, I Jokinen, Pekka Hannonen, Jorma Ilonen

Decreased immunoglobulin production in pokeweed mitogen driven lymphocyte cultures has been reported in rheumatoid arthritis (RA). Here various activators and experimental designs have been used to determine the contribution of B cells, T cells, or m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9817ce309ddd439df0727b6711a2cf23
https://europepmc.org/articles/PMC1004138/

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Synthesis of IgM, IgG and IgA in rheumatoid arthritis

Autor: I Jokinen, Timo Möttönen, K Poikonen, H Arvilommi, Martti Oka

Publikováno v: Annals of the Rheumatic Diseases. 41:607-611

We studied the production of immunoglobulins by lymphocytes separated from the blood of 15 rheumatoid arthritis (RA) patients, of 12 patients suffering from other connective tissue diseases (CTD), and of 18 healthy controls. The production of IgM, Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb50a8df4f460800d1f3b862a199cfe5
https://doi.org/10.1136/ard.41.6.607

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Francisella tularensis-specific T-cell clones are human leukocyte antigen class II restricted, secrete interleukin-2 and gamma interferon, and induce immunoglobulin production

Autor: Jorma Ilonen, Heljä-Marja Surcel, E Herva, K Poikonen

Publikováno v: Infection and Immunity. 57:2906-2908

T-cell clones (TLC) were established from a Francisella tularensis-vaccinated subject in order to study the cells responsive for cell-mediated immunity against F. tularensis. All the clones were human leukocyte antigen (HLA) class II restricted to on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ede5343fced411fcaa64af52a58858
https://doi.org/10.1128/iai.57.9.2906-2908.1989

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Nocardia water soluble mitogen (NWSM), a human B-lymphocyte mitogen

Autor: K. Asikainen, A. Toivola, K. Poikonen, A. Tiilikainen, Sylvi Silvennoinen-Kassinen, J.A. Vilpo

Publikováno v: International journal of immunopharmacology. 8(8)

Nocardia water soluble mitogen (NWSM), which is a peptidoglycan, was prepared from Nocardia opaca. Its effect on human B-lymphocyte proliferation, the number of immunoglobulin secreting B-cells, and bone marrow stem cell growth was studied in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b3ac3240523c95daca9746e958e279
https://pubmed.ncbi.nlm.nih.gov/3492453

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Selenium and immune functions in humans

Autor: Liisa Räsänen, J Foreman, O Muukkonen, I Jokinen, Heikki Arvilommi, J K Huttunen, K Poikonen

Publikováno v: Infection and immunity. 41(1)

Earlier animal experiments have shown that selenium depletion may decrease immune functions. In this human study, 40 volunteers from a population with low serum selenium concentrations were supplemented with selenium or placebo for 11 weeks. Blood sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5261fee1467dc28522fd1456e5a0a7b4
https://pubmed.ncbi.nlm.nih.gov/6862626

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