Výsledky vyhledávání - "K P Myu, Mai Ja"

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

Autor: Derek J. Hausenloy, K P Myu Mai Ja, Chrishan J A Ramachandra, Shuo Cong, Winston Shim, Jasper Chua

Publikováno v: Antioxidants & Redox Signaling. 32:1135-1149

Significance: Myeloperoxidase (MPO) is a heme peroxidase that is primarily expressed by neutrophils. It has the capacity to generate several reactive species, essential for its inherent antimicrobial activity and innate host defense. Dysregulated MPO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b5913c1e8f3ba792e0c284aeb01282
https://doi.org/10.1089/ars.2019.7971

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Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes

Autor: Winston Shim, Jean-Paul Kovalik, Chrishan J A Ramachandra, K P Myu Mai Ja, Ashish Mehta, Regina Fritsche-Danielson, Derek J. Hausenloy, Ratan Bhat, Philip Wong

Publikováno v: International Journal of Cardiology. 272:288-297

Background Preferential utilization of fatty acids for ATP production represents an advanced metabolic phenotype in developing cardiomyocytes. We investigated whether this phenotype could be attained in human induced pluripotent stem cell derived car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9256da85a1f60430ad19bee56d553ef2
https://doi.org/10.1016/j.ijcard.2018.08.069

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Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

Autor: Philip Wong, Nur Izzah Ismail, K P Myu Mai Ja, Hector A. Cabrera-Fuentes, Gustavo E. Crespo-Avilan, Ying-Hsi Lin, Sang Bing Ong, Jin Jiat Toh, En Ping Yap, Khairunnisa Katwadi, Song-Yi Lim, Chrishan J A Ramachandra, Sauri Hernández-Reséndiz, Nicole Tee, Winston Shim, Xiu-Yi Kwek, Derek J. Hausenloy

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 16, p 3972 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 16

Background: New treatments are needed to reduce myocardial infarct size (MI) and prevent heart failure (HF) following acute myocardial infarction (AMI), which are the leading causes of death and disability worldwide. Studies in rodent AMI models show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6997f969c3650a1cd65c170b2e9a529
https://www.mdpi.com/1422-0067/20/16/3972

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INDUCED PLURIPOTENT STEM CELLS FOR MODELLING ENERGETIC ALTERATIONS IN HYPERTROPHIC CARDIOMYOPATHY

Autor: Chrishan J A, Ramachandra, K P Myu, Mai Ja, Ying-Hsi, Lin, Winston, Shim, William A, Boisvert, Derek J, Hausenloy

Publikováno v: Cond Med

Hypertrophic cardiomyopathy (HCM) is one of the most commonly inherited cardiac disorders that manifests with increased ventricular wall thickening, cardiomyocyte hypertrophy, disarrayed myofibers and interstitial fibrosis. The major pathophysiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::75f19448e7681207472fe78823132f07
https://europepmc.org/articles/PMC7250397/

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ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells

Autor: Winston Shim, Chrishan J A Ramachandra, Chong Hui Lua, K P Myu Mai Ja, Anuja Chitre, Ashish Mehta

Publikováno v: Stem Cells. 34:2461-2470

Mechanisms determining intrinsic differentiation bias inherent to human pluripotent stem cells (hPSCs) toward cardiogenic fate remain elusive. We evaluated the interplay between ErbB4 and Epidemal growth factor receptor (EGFR or ErbB1) in determining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b353af96052478876ba895d5687ef7
https://doi.org/10.1002/stem.2420

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Construction of a vascularized hydrogel for cardiac tissue formation in a porcine model

Autor: Winston Shim, Allen Chen, K P Myu Mai Ja, Chrishan J A Ramachandra, Steve Oh, Kee Pah Lim, Sherwin Ting, Ashish Mehta, Shi Qi Li, Philip Wong, Nicole Tee

Publikováno v: Journal of tissue engineering and regenerative medicine. 12(4)

Replacing cardiac tissues lost to myocardial infarction remains a therapeutic goal for regenerative therapy in recovering cardiac function. We assessed the feasibility of constructing a macrosized human cardiac tissue construct using pluripotent stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba059629421bf8e08e1fb8f94c7539b
https://pubmed.ncbi.nlm.nih.gov/29266858

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Electrotonic coupled metabolic purification of chick cardiomyocytes

Autor: Winston, Shim, Haiyang, Yu, K P Myu Mai, Ja, Muhammad, Parasuram, Kee Pah, Lim, Philip, Wong

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1299

Cardiomyocytes isolated from chick and rodent are widely used in studying cardiac physiology. However, contaminating non-cardiomyocytes are an inherent problem that hinders downstream analysis. Here, we report a novel electrical stimulation coupled w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3857c01e2622680fbb8084a34c6757c8
https://pubmed.ncbi.nlm.nih.gov/25836584

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Electrotonic Coupled Metabolic Purification of Chick Cardiomyocytes

Autor: Haiyang Yu, Winston Shim, Kee Pah Lim, K P Myu Mai Ja, Muhammad Parasuram, Philip Wong

Publikováno v: Methods in Molecular Biology ISBN: 9781493925711

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b7f782b264e449fac970b0f4185ae05
https://doi.org/10.1007/978-1-4939-2572-8_14

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