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Bone marrow toxicity in mice treated with indium-114m-labelled blood cells

Autor: K P, Hoyes, P J, Wadeson, B, Murby, H L, Sharma, R A, Cowan, B I, Lord

Publikováno v: Journal of experimentalclinical cancer research : CR. 20(4)

Clinical trials with autologous indium-114m-labelled lymphocytes have revealed significant anti-tumour effects in chronic lymphocytic leukaemia patients with highly resistant disease. Substitution of the lymphocyte vector with heat-damaged red blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32c9eb832016e5d3080e8f63971673ae
https://pubmed.ncbi.nlm.nih.gov/11876543

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Hemopoietic damage and induction of leukemia in offspring due to preconception paternal irradiation from incorporated plutonium-239

Autor: B I, Lord, K P, Hoyes

Publikováno v: Radiation research. 152

Preconception paternal irradiation has been implicated in a localized excess of childhood leukemia and non-Hodgkin's lymphoma close to a nuclear reprocessing plant. Other epidemiological studies, however, threw doubt on the validity of this hypothesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d104da746102dae73638c6bb65cbf211
https://pubmed.ncbi.nlm.nih.gov/10950687

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Loss of atm radiosensitizes multiple p53 null tissues

Autor: C H, Westphal, K P, Hoyes, C E, Canman, X, Huang, M B, Kastan, J H, Hendry, P, Leder

Publikováno v: Cancer research. 58(24)

An unusual clinical finding in ataxia-telangiectasia, a human disorder caused by mutations in atm, is exquisite sensitivity to gamma irradiation. By contrast, homozygous deletion of p53 is marked by radiation resistance in certain tissue compartments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b729ef6e3dc3e0082f32953a6f185fb
https://pubmed.ncbi.nlm.nih.gov/9865712

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Transferrin-dependent uptake and dosimetry of Auger-emitting diagnostic radionuclides in human spermatozoa

Autor: K P, Hoyes, J S, Nettleton, R S, Lawson, I D, Morris

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 39(5)

Localization of Auger-emitting radionuclides within spermatozoa could lead to the induction of transmissible genetic damage. We have quantified in vitro uptake of the widely used diagnostic Auger-emitters, (111)In and 99mTc, by ejaculated human sperm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f74daa92342a558c62c7fcd7a84995d1
https://pubmed.ncbi.nlm.nih.gov/9591597

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Transferrin-mediated uptake of radionuclides by the testis

Autor: K P, Hoyes, I D, Morris, J H, Hendry, H L, Sharma

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 37(2)

In an attempt to explain the deleterious effects of gonadal radionuclide localization, we examined the role of transferrin in testicular radionuclide uptake.In vivo testicular uptake and retention of the transferrin binding radionuclides 114mIn-citra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b3a70fc97607c924e28957439a28e36
https://pubmed.ncbi.nlm.nih.gov/8667073

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15. Fractionated 114mIn therapy for lymphoid malignancy

Autor: D. Gunton, B. Murby, K. P. Hoyes, Richard A Cowan, S Owens

Publikováno v: Nuclear Medicine Communications. 24:448-449

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c99ae8a4e391e9a37d4f0992842e5ca
https://doi.org/10.1097/00006231-200304000-00034

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Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m

Autor: K P, Hoyes, H L, Sharma, H, Jackson, J H, Hendry, I D, Morris

Publikováno v: Radiation research. 139(2)

The cytotoxic and mutagenic consequences of systemic administration of 114mIn have been examined. Adult male rats were dosed intraperitoneally with 14.8 or 3.7 MBq/kg 114mIn. Approximately 0.25% of the injected radioactivity was localized within the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2349aa8a76bec028e78cf580d159257
https://pubmed.ncbi.nlm.nih.gov/8052694

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In vivo induction of O6-alkylguanine-DNA-alkyltransferase in response to indium-114m

Autor: R E, Wilson, K P, Hoyes, I D, Morris, H L, Sharma, J H, Hendry, G P, Margison

Publikováno v: Radiation research. 138(1)

The effect of systemic administration of the radionuclide 114mIn on O6-alkylguanine-DNA-alkyltransferase (ATase) activity has been examined in rats. In response to 14.8 MBq/kg 114mIn injected intraperitoneally, hepatic ATase was induced maximally app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4472f21bc612ff46979d8c7e23b097b9
https://pubmed.ncbi.nlm.nih.gov/8146297

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