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Akademický článek

Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy

Autor: Peter Vajkoczy, Michael D. Menger, Brigitte Vollmar, Lothar Schilling, Peter Schmiedek, K. Peter Hirth, Axel Ullrich, T.Annie T. Fong

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 1, Iss 1, Pp 31-41 (1999)

Vascular endothelial growth factor (VEGF) plays a fundamental role in mediating tumor angiogenesis and tumor growth. Here we investigate the direct effect of a novel small molecule inhibitor of the Flk-1-mediated signal transduction pathway of VEGF,

Externí odkaz: https://doaj.org/article/9a42472f19d94ff8a358d24b5e68f03b

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(1)

In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate the activities of all three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3efd4191219eb4895f357d4c4cb6cd2
https://pubmed.ncbi.nlm.nih.gov/19116277

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SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors

Publikováno v: Cancer research. 60(15)

Vascular endothelial growth factor, fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) and their cognate receptor tyrosine kinases are strongly implicated in angiogenesis associated with solid tumors. Using rational drug design

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::272b84dc5c1b6c3808e021235f7c5fb2
https://pubmed.ncbi.nlm.nih.gov/10945623

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Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC

Autor: P, Vajkoczy, M D, Menger, R, Goldbrunner, S, Ge, T A, Fong, B, Vollmar, L, Schilling, A, Ullrich, K P, Hirth, J C, Tonn, P, Schmiedek, S A, Rempel

Publikováno v: International journal of cancer. 87(2)

The solid growth of high-grade glioma appears to be critically dependent on tumor angiogenesis. It remains unknown, however, whether the diffuse infiltration of glioma cells into healthy adjacent tissue is also dependent on the formation of new tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4374e743cd2170f00a87a8e433ca4ec
https://pubmed.ncbi.nlm.nih.gov/10861485

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SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

Autor: T A, Fong, L K, Shawver, L, Sun, C, Tang, H, App, T J, Powell, Y H, Kim, R, Schreck, X, Wang, W, Risau, A, Ullrich, K P, Hirth, G, McMahon

Publikováno v: Cancer research. 59(1)

SU5416, a novel synthetic compound, is a potent and selective inhibitor of the Flk-1/KDR receptor tyrosine kinase that is presently under evaluation in Phase I clinical studies for the treatment of human cancers. SU5416 was shown to inhibit vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b18d32723f239cc2f69630eb337adf62
https://pubmed.ncbi.nlm.nih.gov/9892193

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Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide

Autor: L K, Shawver, D P, Schwartz, E, Mann, H, Chen, J, Tsai, L, Chu, L, Taylorson, M, Longhi, S, Meredith, L, Germain, J S, Jacobs, C, Tang, A, Ullrich, M E, Berens, E, Hersh, G, McMahon, K P, Hirth, T J, Powell

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(7)

Many reports have cited coexpression of platelet-derived growth factor (PDGF) and its receptors by tumor cells or cells supporting tumor growth, suggesting both autocrine and paracrine mechanisms for PDGF-mediated tumor growth. We found that a small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07b1460cb56b4a178ca55ef3c97d3e5a
https://pubmed.ncbi.nlm.nih.gov/9815796

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Flk-1 as a target for tumor growth inhibition

Autor: L M, Strawn, G, McMahon, H, App, R, Schreck, W R, Kuchler, M P, Longhi, T H, Hui, C, Tang, A, Levitzki, A, Gazit, I, Chen, G, Keri, L, Orfi, W, Risau, I, Flamme, A, Ullrich, K P, Hirth, L K, Shawver

Publikováno v: Cancer research. 56(15)

A number of growth factor receptor tyrosine kinases have been implicated in angiogenesis, including epidermal growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, Flk-1/KDR, Flt-1, Tie-1, and Tek/Tie-2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa130fc41c0e5a7e3b824aa1dd7ceed0
https://pubmed.ncbi.nlm.nih.gov/8758924

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The bacterial factors which stimulate neutrophils may be derived from procaryote signal peptides

Autor: J P, Bennett, K P, Hirth, E, Fuchs, M, Sarvas, G B, Warren

Publikováno v: FEBS Letters. 116:57-61

During the inflammatory response associated with most bacterial infections, neutrophils migrate into tissues containing viable bacteria and participate in their elimination from the tissue. The migration of neutrophils to the site of infection is pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da04cb738bbd3b9f4a4c8b2f7e70ba91
https://doi.org/10.1016/0014-5793(80)80528-x

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Inheritance of extrachromosomal ribosomal DNA during the asexual life cycle of Dictyostelium discoideum: examination by use of DNA polymorphisms

Autor: K L Williams, K P Hirth, D L Welker

Publikováno v: Molecular and Cellular Biology. 5:273-280

Wild-type isolates of Dictyostelium discoideum exhibited differences in the size of restriction fragments of the extrachromosomal 88-kilobase ribosomal DNA (rDNA) palindrome. Polymorphisms in rDNA also were found among strains derived solely from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d98fabebe407ed6e94012688404a6358
https://doi.org/10.1128/mcb.5.2.273

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A DNA-mediated transformation system for Dictyostelium discoideum

Autor: C A Edwards, K P Hirth, Richard A. Firtel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 79(23)

We have established a transformation system for Dictyostelium discoideum. The transformation vector contains the protein coding region of the Tn5 neomycin resistance gene fused to the proposed promoter of the Dictyostelium actin 8 gene; the vector al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f6c8121ffa624fdcd4e9fac7ffb3d6
https://pubmed.ncbi.nlm.nih.gov/6296830

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