Zobrazeno 1 - 10
of 44
pro vyhledávání: '"K O, Lindros"'
Publikováno v:
Biochemical Journal. 282:635-638
The expression and induction of the cytochrome P450 2B1/2 isoenzyme is heterogeneous, exhibiting a regional pattern in the intact liver and a varied response to phenobarbital in isolated cultured hepatocytes. We report that P450 2B1/2 immunostaining
Publikováno v:
Scandinavian journal of gastroenterology. 38(12)
Kupffer cells can release pro-inflammatory mediators and contribute to damage, which often appears in a zonated fashion.To assess position-associated functional differences, functions of intact Kupffer cells isolated from either the periportal or per
Publikováno v:
Alcoholism, clinical and experimental research. 25(5 Suppl)
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Nobuhiro Sato and Kai O. Lindros. The presentations were (1) Sex differences in ethanol pharmacokinetics, by E. Baraona; (2) Estrogen
Acetaldehyde prevents nuclear factor-kappa B activation and hepatic inflammation in ethanol-fed rats
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 79(7)
Acetaldehyde has been proposed as one of the mediators of liver injury in alcoholic liver disease. We investigated whether increased acetaldehyde levels affected the development of alcoholic liver injury. Male Wistar rats were fed a liquid diet conta
Publikováno v:
Hepatology (Baltimore, Md.). 29(5)
To better understand how gut-derived endotoxins influence alcohol-induced liver injury and the expression of inflammatory cytokines a new animal model was developed. After 2 weeks on a modified ethanol-containing liquid diet, some rats also were infu
Publikováno v:
Alcoholism, clinical and experimental research. 21(8)
Gut-derived endotoxins (lipopolysaccharide, LPS) are believed to contribute to alcohol-induced liver disease (ALD) by stimulating Kupffer cells, the resident liver macrophages, to release proinflammatory cytokines. This activation is largely mediated
Publikováno v:
Cell biology and toxicology. 13(4-5)
Within the liver acinus the majority of genes are expressed in an ascending or descending gradient from the portal to the central vein. The regulatory factors involved in this spatial pattern of gene expression are still poorly understood. Many liver
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
The aryl hydrocarbon receptor (AHR) is a transcriptional activator of genes encoding a group of drug-metabolizing enzymes, including cytochrome P450 1A1 (CYP1A1), glutathione S-transferase, tumor-associated aldehyde dehydrogenase and quinone reductas
Autor:
M, Koivusalo, K O, Lindros
Publikováno v:
Advances in experimental medicine and biology. 414
Publikováno v:
Biochemical pharmacology. 51(10)
The effect of hypophysectomy and subsequent infusion of growth hormone (GH) or injections of triiodothyronine (T3) on the acinar expression pattern of four homonally regulated P450 isozymes was studied to elucidate the involvement of pituitary depend