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Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells

Autor: K O, Hicks, F B, Pruijn, B C, Baguley, W R, Wilson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 297(3)

There is considerable evidence that DNA intercalating drugs fail to penetrate tumor tissue efficiently. This study used the multicellular layer (MCL) experimental model, in conjunction with computational modeling, to test the hypothesis that a DNA in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00d09200bac43ef0e30cc235cb3bb9f1
https://pubmed.ncbi.nlm.nih.gov/11356933

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