Zobrazeno 1 - 10
of 10
pro vyhledávání: '"K N Koliasnikova"'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 50-55 (2023)
Background. Cyclo-L-prolylglycine (CPG) was designed and synthesized at the V.V. Zakusov as a topological analogue of the classical nootrop piracetam and was further identified as an endogenous compound. Previously, the nootropic effect of CPG was
Externí odkaz:
https://doaj.org/article/c9034e386a724e5da60cea30e5df46cb
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 20-25 (2022)
The article presents the results of studying the pharmacokinetics and enzymatic stability of a new pharmacologically active compound GZK-111– N-phenylacetyl-glycyl-L-proline ethyl ether in comparison with noopept – N-phenylacetyl-L-prolyl-glycine
Externí odkaz:
https://doaj.org/article/ab6c4ba02ec34d1096dbb89434f68429
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 18-23 (2022)
Thе article represents a review of our own researches, which describes the design, synthesis and pharmacological properties of linear substituted glyproline GZK-111, a potential drug for the complex treatment of psychiatric pathologies, including an
Externí odkaz:
https://doaj.org/article/a89ef1490c9d432cbaa34b219107f9d0
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 36-41 (2022)
The review presents the results of studies on the pharmacokinetics, metabolism, and bioavailability of new neurotropic dipeptide cyclo-Lprolilglycine (CPG) and their pharmacological activity. It was shown that the pharmacologically active metabolite
Externí odkaz:
https://doaj.org/article/839503dc85214b57a4976c5fd883084d
Autor:
S. V. Nikolaev, I. O. Logvinov, K. N. Koliasnikova, E. A. Kuznetsova, P. I. Antipov, T. A. Antipova
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 4-10 (2020)
In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability. The ethyl
Externí odkaz:
https://doaj.org/article/981ab3fc6c494b46911222eb9cac8c93
Autor:
T. A. Gudasheva, K. N. Koliasnikova, A. G. Alyaeva, S. V. Nikolaev, T. A. Antipova, S. B. Seredenin
Publikováno v:
Doklady Biochemistry and Biophysics. 507:264-267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c4d75ecea3997bd9ad20bc5cfeb6ae
https://doi.org/10.1134/s1607672922060047
https://doi.org/10.1134/s1607672922060047
Publikováno v:
Problems of Biological Medical and Pharmaceutical Chemistry. 23:42-45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca79c58af5ea22ef1cb65423fefb9b0
https://doi.org/10.29296/25877313-2020-09-06
https://doi.org/10.29296/25877313-2020-09-06
Autor:
Tatiana A Gudasheva, K N Koliasnikova, P. Yu. Povarnina, S. B. Seredenin, A.G. Alyaeva, O. N. Vorontsova
Publikováno v:
Doklady. Biochemistry and biophysics. 493(1)
Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eb93262271f0adb385b613068e0e6a
https://pubmed.ncbi.nlm.nih.gov/32894462
https://pubmed.ncbi.nlm.nih.gov/32894462
Publikováno v:
Doklady Biochemistry and Biophysics. 469:273-276
It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10(-7) and 10(-3) M and piracetam at a concentration of 10(-3) M increased the content of brainderived neurotrophic factor (BDNF) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b5078d29cce1f8b3203df0663df536
https://doi.org/10.1134/s1607672916040104
https://doi.org/10.1134/s1607672916040104
Publikováno v:
Doklady Biochemistry and Biophysics. 471:387-389
We have previously shown that neuropeptide cycloprolylglycine (CPG) increases the content of brain-derived neurotrophic factor (BDNF) in the culture of neuronal cells under normal conditions and in pathology. This is the first study to show that CPG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085c2ffca6e51bf6fa87d583b647293c
https://doi.org/10.1134/s160767291606003x
https://doi.org/10.1134/s160767291606003x