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Akademický článek
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Autor:
Veronica Fagerholm, K. Någren, Saila Kauhanen, Eveliina Arponen, Pirjo Nuutila, Olof Solin, Kirsi Mikkola, Merja Haaparanta, Tamiko Ishizu
Publikováno v:
Journal of Nuclear Medicine; Vol 51
Journal of Nuclear Medicine
Journal of Nuclear Medicine
Vesicular monoamine transporter 2 (VMAT2) is a putative molecular target for the quantitative imaging of pancreatic beta-cell mass by PET. The VMAT2 PET tracer (11)C-dihydrotetrabenazine ((11)C-DTBZ) exhibits high pancreatic uptake that is reduced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b85975ecae25466ba4858ee54f1daa
https://doi.org/10.2967/jnumed.109.074492
https://doi.org/10.2967/jnumed.109.074492
Publikováno v:
NeuroImage. 51:918-922
Introduction It has been previously reported that hippocampal dopamine D2/D3 receptors are involved in the regulation of verbal memory and learning in healthy volunteers. We tested this hypothesis further and studied whether cortical dopamine D2/D3 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d612cfeb539e22bff7af73ca4d421b
https://doi.org/10.1016/j.neuroimage.2010.02.039
https://doi.org/10.1016/j.neuroimage.2010.02.039
Autor:
Terhi Tuokkola, Jarkko Johansson, Matti Laine, Sargo Aalto, Juha O. Rinne, K. Någren, Kati Alakurtti, Vesa Oikonen
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 31:155-165
Positron emission tomography (PET) imaging of small striatal brain structures such as the ventral striatum (VST) has been hampered by low spatial resolution causing partial-volume effects. The high-resolution research tomograph (HRRT) is a brain-dedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907c3da452ed927a252dd70fb03b5dc9
https://doi.org/10.1038/jcbfm.2010.64
https://doi.org/10.1038/jcbfm.2010.64
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 37:606-612
The positron emission tomography (PET) radiotracer (11)C-(R)-PK11195 allows the in vivo imaging in humans of the translocator protein 18 kDa (TSPO), previously called peripheral benzodiazepine receptor (PBR), a marker of inflammation. Despite its wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d828ce5fbc311790ab4f245438fdde
https://doi.org/10.1007/s00259-009-1298-3
https://doi.org/10.1007/s00259-009-1298-3
Autor:
K. Någren, Ullamari Pesonen, Tero Vahlberg, Nora Hagelberg, Jarmo Hietala, Juha O. Rinne, Mika M. Hirvonen
Publikováno v:
Molecular Imaging and Biology. 12:192-197
Catechol-O-methyl transferase (COMT) is a pivotal regulator of brain dopamine function with a region-specific role. COMT is important in dopamine elimination in the prefrontal cortex, whereas dopamine reuptake is the main mechanism for synaptic remov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c537b736d50976a3e965b1531f955e
https://doi.org/10.1007/s11307-009-0257-5
https://doi.org/10.1007/s11307-009-0257-5
Autor:
K. Någren, Ullamari Pesonen, Mika M. Hirvonen, Tero Vahlberg, Jussi Hirvonen, Jarmo Hietala, Ville Lumme, Harry Scheinin
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 33:630-636
The C957T (rs6277) single nucleotide polymorphism (SNP) of the human dopamine D2 receptor (DRD2) gene (DRD2) affects DRD2 mRNA stability and has been shown to predict striatal DRD2 availability (B(max)/K(D)) in vivo in man. Specifically, the C/C geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942b5d77d97844e8c88883d22f69af1c
https://doi.org/10.1016/j.pnpbp.2009.02.021
https://doi.org/10.1016/j.pnpbp.2009.02.021
Publikováno v:
Neurology. 72:1504-1511
To study the relationship between gray matter atrophy and amyloid deposition in Alzheimer disease (AD).Volumetric magnetic resonance (MR) and [11C]-PIB PET were acquired from 23 patients with AD and 17 healthy older persons. Standardized [11C]-PIB up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f62e0724d855ab0dc817ca50b1dcf3
https://doi.org/10.1212/wnl.0b013e3181a2e896
https://doi.org/10.1212/wnl.0b013e3181a2e896
Autor:
Juha O. Rinne, Riitta Parkkola, Nina Kemppainen, Juho Joutsa, Johanna Rokka, Jarkko Johansson, K. Någren, Noora M. Scheinin
Publikováno v:
Kemppainen, N, Joutsa, J, Johansson, J, Scheinin, N M, Någren, K, Rokka, J, Parkkola, R & Rinne, J O 2015, ' Long-Term Interrelationship between Brain Metabolism and Amyloid Deposition in Mild Cognitive Impairment ', Journal of Alzheimer's disease : JAD, vol. 48, no. 1, pp. 123-133 . https://doi.org/10.3233/JAD-150190
The aim of this longitudinal positron emission tomography (PET) study was to evaluate the interrelationship between brain metabolism and amyloid accumulation during the disease process from mild cognitive impairment (MCI) to Alzheimer's disease (AD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad7996d97f94540cc7fe81dfb0b6b61
https://pubmed.ncbi.nlm.nih.gov/26401934
https://pubmed.ncbi.nlm.nih.gov/26401934
Autor:
A. Brück, K. Någren, Marita Kailajärvi, Riitta Parkkola, I. A. Wilson, Matti Viitanen, Nina Kemppainen, Vesa Oikonen, Sargo Aalto, Juha O. Rinne, Mika Scheinin, Semi Helin
Publikováno v:
Neurology. 67:1575-1580
PET studies with N-methyl-[(11)C]2-(4':-methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB) have revealed an increased tracer uptake in several brain regions in Alzheimer disease (AD).To employ voxel-based analysis method to identify brain regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d7f9277aa6f49dfc46e37c85e412f7
https://doi.org/10.1212/01.wnl.0000240117.55680.0a
https://doi.org/10.1212/01.wnl.0000240117.55680.0a