Zobrazeno 1 - 10
of 64
pro vyhledávání: '"K Misterek"'
Publikováno v:
Life sciences. 66(4)
The present study was undertaken to investigate the role of inducible nitric oxide synthase in a rat model of persistent pain. The effects of L-N6 (1-iminoethyl) lysine (L-NIL), a relatively potent and relatively selective inhibitor of inducible nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea557b5a931182b964217f375c7c2240
https://pubmed.ncbi.nlm.nih.gov/10665981
https://pubmed.ncbi.nlm.nih.gov/10665981
Publikováno v:
Polish journal of pharmacology and pharmacy. 43(5)
Synthesis of four new N,N-disubstituted derivatives of enkephalin analogs: All2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 5, Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-OMe 6, All2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon Ahx-OMe 11 and Bu2Tyr-DMet-Gly-Phe-epsilon Ahx-epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bf297b5f96dffc042790ed7c6247ebc
https://pubmed.ncbi.nlm.nih.gov/1824127
https://pubmed.ncbi.nlm.nih.gov/1824127
Publikováno v:
Polish journal of pharmacology and pharmacy. 43(2)
Synthesis of four new derivatives of enkephalin analogs: H-BuTyr-DMet-Gly- Phe-epsilon Ahx-OH 9, H-BzlTyr-DMet-Gly-Phe-epsilon Ahx-OH 12, H-Butyr-DMet-Gly- -Phe-epsilon Ahx-epsilon Ahx-OH 15 and H-BzlTyr-DMet-Gly-Phe-epsilon Ahx-OH is reported. They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b69836569e3b256a847d83a851d7733
https://pubmed.ncbi.nlm.nih.gov/1658758
https://pubmed.ncbi.nlm.nih.gov/1658758
Publikováno v:
Polish journal of pharmacology and pharmacy. 42(5)
A new hexapeptide analog of Substance P, containing a C-terminal thioamide group in the molecule [( Glp6, Mett11]SP6-11) was synthesized: Glp-Phe-Phe-Gly-Leu-Mett-NH2. Conversion to thioamide was accomplished from tert-butoxycarbonyl-L-methionine ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c42e44facf5cfa48087c2ded0c18204e
https://pubmed.ncbi.nlm.nih.gov/1711685
https://pubmed.ncbi.nlm.nih.gov/1711685
Publikováno v:
Regulatory Peptides. 53:S127-S128
Hybridization of benzomorphan alkaloids with opioid peptide «addresses» is one of the successful method of modulation of receptor selectivity and affinity of opioid ligands. In this paper we present biological properties of two new compounds, hybri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2202ba24083315ae3db5ba70779396
https://doi.org/10.1016/0167-0115(94)90274-7
https://doi.org/10.1016/0167-0115(94)90274-7
Autor:
Rudolf Fitzner, J-P Tessmann, C Mannheim Spies, K Misterek, Klaus Schröder, C Sanft, Walter Schaffartzik, A Enders, Ortrud Vargas Hein
Publikováno v:
Critical Care
Tissue ischemia and organ failure are considered to be main reasons for the high mortality in septic patients. In the past years therapy of septic shock has changed. The therapeutic goal is no longer a supranormal DO2 (DO2 > 600 ml/min/m2), but the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cdd5477f66f371e55f871b7d90346e
https://doi.org/10.1186/cc88
https://doi.org/10.1186/cc88
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 321:105-111
Rats were made tolerant to morphine or to DALA, a synthetic analogue of met-enkephalin, by prolonged exposure to these compounds. Tolerance was assessed by evaluating the resistance of the treated rats to present catalepsy after an acute dose of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcec75706c20d835da485e70459647d7
https://doi.org/10.1007/bf00518476
https://doi.org/10.1007/bf00518476
Publikováno v:
Polish journal of pharmacology and pharmacy. 33(1)
Amino acid derivatives of benzocaine have shown local anesthetic properties similar to procaine in infiltration and block anesthesia tests, but were ineffective after topic application. Metabolic studies revealed the possibility of rapid hydrolysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24be4a534712d33703af9f94ab9068a1
https://pubmed.ncbi.nlm.nih.gov/7255285
https://pubmed.ncbi.nlm.nih.gov/7255285
Publikováno v:
Polish medical sciences and history bulletin. 15(1)
Newly synthesized L-leucine-4-antipyrineamide shows the biological effect of aminopyrine. In contrast, it does not cause any adverse effect on the growth of rat, and induces neither degeneration of the parenchymal organs nor agranulocytosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f04d241bf00e27db2bd8de6c579bba8f
https://pubmed.ncbi.nlm.nih.gov/1223800
https://pubmed.ncbi.nlm.nih.gov/1223800
Publikováno v:
Polish journal of pharmacology and pharmacy. 34(5-6)
4-propionyl-4-(4-chlorophenyl)-1-(3-dimethylaminopropyl)-piperidine dihydro-chloride (S8) showed in the hot plate test a marked analgesic activity with a better therapeutic index than that of pethidine. S8 possesses also anti-inflammatory (in short a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8882878ace4638adec12b00ba56e7bb1
https://pubmed.ncbi.nlm.nih.gov/6985303
https://pubmed.ncbi.nlm.nih.gov/6985303