Zobrazeno 1 - 10
of 13
pro vyhledávání: '"K Melodi McSweeney"'
Autor:
Sahar Gelfman, Quanli Wang, Yi-Fan Lu, Diana Hall, Christopher D Bostick, Ryan Dhindsa, Matt Halvorsen, K Melodi McSweeney, Ellese Cotterill, Tom Edinburgh, Michael A Beaumont, Wayne N Frankel, Slavé Petrovski, Andrew S Allen, Michael J Boland, David B Goldstein, Stephen J Eglen
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006506 (2018)
Here we present an open-source R package 'meaRtools' that provides a platform for analyzing neuronal networks recorded on Microelectrode Arrays (MEAs). Cultured neuronal networks monitored with MEAs are now being widely used to characterize in vitro
Externí odkaz:
https://doaj.org/article/5b8630b3daec46ff9fb096ee125ae13c
Publikováno v:
Cancer Metastasis Reviews
The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation
Publikováno v:
Cell Death Discovery, Vol 5, Iss 1, Pp 1-11 (2019)
Cell Death Discovery
Cell Death Discovery
Doxorubicin is an important anticancer drug in the clinic. Unfortunately, it causes cumulative and dose-dependent cardiotoxic side effects. As the population of cancer survivors who have been exposed to treatment continues to grow, there is increased
Autor:
Tom Edinburgh, David Goldstein, Andrew S. Allen, Ellesse Cotterill, Diana Hall, Matt Halvorsen, Ryan S. Dhindsa, Michael A. Beaumont, Quanli Wang, Sahar Gelfman, Wayne N. Frankel, Christopher D. Bostick, Stephen J. Eglen, K. Melodi McSweeney, Slavé Petrovski, Yi-Fan Lu, Michael J. Boland
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 10, p e1006506 (2018)
Here we present an open-source R package ‘meaRtools’ that provides a platform for analyzing neuronal networks recorded on Microelectrode Arrays (MEAs). Cultured neuronal networks monitored with MEAs are now being widely used to characterize in vi
Autor:
Dana Jazayeri, Melody Li, David Goldstein, Erin L. Heinzen, Ben Corry, K. Melodi McSweeney, Steven Petrou
Publikováno v:
Neurobiology of Disease, Vol 77, Iss, Pp 88-93 (2015)
Objective Mutations in ATP1A3, the gene that encodes the α3 subunit of the Na+/K+ ATPase, are the primary cause of alternating hemiplegia of childhood (AHC). Correlations between different mutations and AHC severity were recently reported, with E815
Autor:
Quanli Wang, Sahar Gelfman, David Goldstein, Michael J. Boland, Shelton S. Bradrick, Wayne N. Frankel, Sarah A. Dugger, K. Melodi McSweeney, Ayal B. Gussow, Slavé Petrovski
Cultured neuronal networks monitored with microelectrode arrays (MEAs) have been used widely to evaluate pharmaceutical compounds for potential neurotoxic effects. A newer application of MEAs has been in the development of in vitro models of neurolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ecd9554d4013dbbae24fbd882a3789
https://europepmc.org/articles/PMC5052052/
https://europepmc.org/articles/PMC5052052/
Autor:
Quanli Wang, Zhong Ren, Erin L. Heinzen, Kelly Schoch, K. Melodi McSweeney, Sahar Gelfman, David Goldstein, Michael J. Boland, Slavé Petrovski, Francesca La Carpia, Fanni Ratzon, Matt Halvorsen
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Identifying the underlying causes of disease requires accurate interpretation of genetic variants. Current methods ineffectively capture pathogenic non-coding variants in genic regions, resulting in overlooking synonymous and intronic variants when s
Autor:
Matt Halvorsen, Zhong Ren, Sahar Gelfman, Michael J. Boland, K. Melodi McSweeney, Kelly Schoch, Slavé Petrovski, Quanli Wang, David Goldstein, Francesca La Carpia, Erin L. Heinzen
Publikováno v:
European Neuropsychopharmacology. 27:S432-S433
Background A central aim of precision medicine is to target treatments to the underlying causes of disease. To accurately target treatments we must be able to recognize pathogenic genetic variants. Current methods prioritize variants that directly al
Autor:
Danit Oz-Levi, Doron Lancet, Yujun Han, Vandana Shashi, Dina Marek-Yagel, Elizabeth K. Ruzzo, Bruria Ben-Zeev, Gali Heimer, David Goldstein, Rebecca C. Spillmann, Yair Anikster, Yong-hui Jiang, Andreea Nissenkorn, Yuki Hitomi, Jennifer L. Goldstein, Elon Pras, K. Melodi McSweeney, Michal Tzadok, Slavé Petrovski, Gordon Worley, Yi-Fan Lu, Xiaolin Zhu, Anna C. Need, Ryan S. Dhindsa, Kelly Schoch, Duncan McHale, Pingxing Xie
Publikováno v:
Genetics in Medicine
Purpose: Despite the recognized clinical value of exome-based diagnostics, methods for comprehensive genomic interpretation remain immature. Diagnoses are based on known or presumed pathogenic variants in genes already associated with a similar pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84ae4c6d5557cf196a86ac4ce34051
http://hdl.handle.net/10044/1/38939
http://hdl.handle.net/10044/1/38939
Autor:
Talal Mousallem, David Goldstein, Mingfu Zhu, Roberta E. Parrott, Brian J. Krueger, Joseph L. Roberts, Mehdi Adeli, Rebecca H. Buckley, Thomas J. Urban, Sarah E. Kleinstein, K. Melodi McSweeney
Publikováno v:
The Journal of allergy and clinical immunology. 136(2)
This report illustrates the value of whole genome sequencing (WGS) in elucidating the genetic cause of disease in patients with primary immunodeficiency (PID). As sequencing costs decline, we predict that utilization of next generation sequencing (NG