Zobrazeno 1 - 10
of 82
pro vyhledávání: '"K Mark Coggeshall"'
Autor:
Marybeth Langer, Alanson W Girton, Narcis I Popescu, Tarea Burgett, Jordan P Metcalf, K Mark Coggeshall
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193207 (2018)
Peptidoglycan (PGN), a major component of bacterial cell walls, is a pathogen-associated molecular pattern (PAMP) that causes innate immune cells to produce inflammatory cytokines that escalate the host response during infection. In order to better u
Externí odkaz:
https://doaj.org/article/02120cd74e8243bf9cdad7fe74a81953
Autor:
Marybeth Langer, Alexander Malykhin, Kenichiro Maeda, Kaushik Chakrabarty, Kelly S Williamson, Christa L Feasley, Christopher M West, Jordan P Metcalf, K Mark Coggeshall
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3706 (2008)
We hypothesized that the peptidoglycan component of B. anthracis may play a critical role in morbidity and mortality associated with inhalation anthrax. To explore this issue, we purified the peptidoglycan component of the bacterial cell wall and stu
Externí odkaz:
https://doaj.org/article/7f65f2d302e44a71a511eff8c7ae6fa9
Autor:
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajaña, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Publikováno v:
Microorganisms, Vol 11, Iss 1, p 173 (2023)
Gram-positive bacterial infections are a major cause of organ failure and mortality in sepsis. Cell wall peptidoglycan (PGN) is shed during bacterial replication, and Bacillus anthracis PGN promotes a sepsis-like pathology in baboons. Herein, we dete
Externí odkaz:
https://doaj.org/article/76338808118045a094a816262c2f125b
Autor:
Robert Silasi, Narcis I. Popescu, Alonso Ricardo, Girija Regmi, Cristina Lupu, K. Mark Coggeshall, Ravi S. Keshari, Florea Lupu, Joe H. Simmons
Publikováno v:
Proc Natl Acad Sci U S A
Late-stage anthrax infections are characterized by dysregulated immune responses and hematogenous spread of Bacillus anthracis, leading to extreme bacteremia, sepsis, multiple organ failure, and, ultimately, death. Despite the bacterium being nonhemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8501584aa74da4203b30a4f515050183
https://doi.org/10.1073/pnas.2104347118
https://doi.org/10.1073/pnas.2104347118
Publikováno v:
Microorganisms, Vol 8, Iss 1039, p 1039 (2020)
Microorganisms
Volume 8
Issue 7
Microorganisms
Volume 8
Issue 7
Neutrophils are the most abundant innate cell population and a key immune player against invading pathogens. Neutrophils can kill both bacterium and spores of Bacillus anthracis, the causative anthrax pathogen. Unlike interactions with professional p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74e6120658b0be6238ccb005c244945
https://www.mdpi.com/2076-2607/8/7/1039
https://www.mdpi.com/2076-2607/8/7/1039
Autor:
David C. Hutchings, Elizabeth S. Duggan, Vicky L. White, Mikhail G. Dozmorov, K. Mark Coggeshall, Dennis Burian, Jordan P. Metcalf, Wenxin Wu, J. Leland Booth, Vineet I. Patel
Publikováno v:
Microbial Pathogenesis. 121:9-21
The lung is the entry site for Bacillus anthracis in inhalation anthrax, the most deadly form of the disease. Spores must escape through the alveolar epithelial cell (AEC) barrier and migrate to regional lymph nodes, germinate and enter the circulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa3f15e024ba4a94a6fdbd3dac83f35
https://doi.org/10.1016/j.micpath.2018.04.039
https://doi.org/10.1016/j.micpath.2018.04.039
Publikováno v:
Blood advances. 3(16)
Disseminated intravascular coagulation is a frequent manifestation during bacterial infections and is associated with negative clinical outcomes. Imbalanced expression and activity of intravascular tissue factor (TF) is central to the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bc5bdc60f09a37586771ead63592ec
https://pubmed.ncbi.nlm.nih.gov/31416821
https://pubmed.ncbi.nlm.nih.gov/31416821
Autor:
Tarea Burgett, K. Mark Coggeshall, Alanson W. Girton, Narcis I. Popescu, Ravi S. Keshari, Florea Lupu
Publikováno v:
Infection and Immunity
We showed that human IgG supported the response by human innate immune cells to peptidoglycan (PGN) from Bacillus anthracis and PGN-induced complement activation. However, other serum constituents have been shown to interact with peptidoglycan, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9094022823d73e511c69f52e7b4402
http://europepmc.org/articles/PMC5913848
http://europepmc.org/articles/PMC5913848
Publikováno v:
B-Lymphocyte Differentiation ISBN: 9781351070010
The ability of the B cell to distinguish among regulatory species is probably determined at multiple levels. These include differential receptor expression, differential receptor coupling to specific second-messenger generating systems, and different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79e5e560cf487a800a9c8d0e5e612b9
https://doi.org/10.1201/9781351070010-1
https://doi.org/10.1201/9781351070010-1
Autor:
Robert Silasi, Narcis I. Popescu, Florea Lupu, Andras Gruber, David Gailani, Tarea Burgett, Ravi S. Keshari, Alanson W. Girton, Sacha Zeerleder, K. Mark Coggeshall
Publikováno v:
Blood, 132(8), 849-860. American Society of Hematology
Anthrax infections exhibit progressive coagulopathies that may contribute to the sepsis pathophysiology observed in fulminant disease. The hemostatic imbalance is recapitulated in primate models of late-stage disease but is uncommon in toxemic models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf0041378e68a5540b64883feff7db4
https://pure.amc.nl/en/publications/peptidoglycan-induces-disseminated-intravascular-coagulation-in-baboons-through-activation-of-both-coagulation-pathways(3df25f87-17c3-48d3-b521-0eb6a39e5235).html
https://pure.amc.nl/en/publications/peptidoglycan-induces-disseminated-intravascular-coagulation-in-baboons-through-activation-of-both-coagulation-pathways(3df25f87-17c3-48d3-b521-0eb6a39e5235).html