Zobrazeno 1 - 10
of 23
pro vyhledávání: '"K M Verburg"'
Autor:
D N Herrmann, K M Verburg, M T Brown, David Keller, P J Dyck, C R West, William Carey, Candace Bramson
Publikováno v:
Journal Club Schmerzmedizin. 4:223-223
Bei der Weiterleitung von Schmerzsignalen spielt der Nerve Growth Factor (NGF) eine zentrale Rolle. NGF moduliert nach Bindung an 2 Rezeptoren an sensorischen Neuronen die Freisetzung von verschiedenen Transmittern, Rezeptoren und Ionenkanalen. Im Ti
Publikováno v:
Scandinavian Journal of Gastroenterology. 26:26-31
Henry DP, Bowsher RR, Verburg KM. Radioenzymatic assay for histamine: development and validation. Scand J Gastroenterol 1991, 26(suppl 180), 26–31Radioenzymatic assays are sensitive analytic tools that use an enzyme to quantify a substrate for that
Autor:
K M Verburg, M T Brown, Joseph Gimbel, A J Kivitz, M Nemeth, David Keller, C R West, Candace Bramson
Publikováno v:
Journal Club Schmerzmedizin. 4:32-32
Bei Tanezumab handelt es sich um einen humanisierten monoklonalen Antikorper gegen den Nerve Growth Factor (NGF), der normalerweise fur die Modulation der nozizeptiven Aktivitat zustandig ist. Tanezumab bindet an den NGF, verhindert dessen Interaktio
Publikováno v:
Alimentary pharmacologytherapeutics. 20(5)
In a predefined analysis, data were pooled from eight blinded, randomized, controlled trials, and separately from three long-term, open-label trials to determine the rate of upper gastrointestinal ulcer complications with the cyclo-oxygenase-2 select
Publikováno v:
Alimentary pharmacologytherapeutics. 18(1)
In long-term outcomes studies, cyclooxygenase COX-2 specific inhibitors spare COX-1 at supratherapeutic doses and therefore demonstrate improved gastrointestinal safety over nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs). However, in clini
Publikováno v:
Rheumatology (Oxford, England). 42(10)
OBJECTIVE: To compare the efficacy and upper gastrointestinal (GI) safety of valdecoxib 20 and 40 mg daily with those of diclofenac 75 mg slow release (SR) twice daily in treating rheumatoid arthritis (RA). METHODS: Seven hundred and twenty-two patie
Autor:
F E, Silverstein, G, Faich, J L, Goldstein, L S, Simon, T, Pincus, A, Whelton, R, Makuch, G, Eisen, N M, Agrawal, W F, Stenson, A M, Burr, W W, Zhao, J D, Kent, J B, Lefkowith, K M, Verburg, G S, Geis
Publikováno v:
JAMA. 284(10)
Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1. Whether COX-2-specific inhibitors are associated with
Publikováno v:
Scandinavian journal of gastroenterology. Supplement. 180
Radioenzymatic assays are sensitive analytic tools that use an enzyme to quantify a substrate for that enzyme. Purified histamine N-methyltransferase has been used as the basis for an assay for histamine. The sensitivity of the procedure is less than
Publikováno v:
The American journal of physiology. 259(1 Pt 2)
This study was designed to investigate in sodium-depleted monkeys the renal hemodynamic and excretory effects resulting from blockade of the renin-angiotensin system induced by intrarenal infusion of the primate-selective renin inhibitor A-65317. Int
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 252(2)
Experiments were conducted in sodium-depleted anesthetized monkeys to determine the effects of the primate-selective renin inhibitor A-64662 on renal function. Five groups of monkeys were examined with each group receiving an i.v. infusion of vehicle