Výsledky vyhledávání

Lipoprotein isolation and analysis from serum by preparative ultracentrifugation

Autor: K M, Wasan, S M, Cassidy, A L, Kennedy, K D, Peteherych

Publikováno v: Methods in molecular medicine. 52

Plasma lipoproteins are a heterogeneous population of soluble, macromolecular aggregates of lipids and proteins. They are responsible for the transport of waterinsoluble nutrients through the vascular and extravascular fluids from their site of synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0480b31f9263ad89848cb73c1c884d5
https://pubmed.ncbi.nlm.nih.gov/21340929

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Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats

Autor: K M, Wasan, K D, Peteherych, S, Najafi, C, Zamfir, P H, Pritchard

Publikováno v: Journal of pharmacypharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 4(3)

The purpose of this project was to 1) assess the disposition kinetics of [3H]-cholesterol following co-administration with a novel hydrophilic compound, FM-VP4, and 2) determine the pharmacokinetics, tissue distribution and excretion of [3H]FM-VP4 fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06c81c40bec0f021cf389c1701240c78
https://pubmed.ncbi.nlm.nih.gov/11737986

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Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils

Autor: K M, Wasan, S, Najafi, J, Wong, M, Kwong, P H, Pritchard

Publikováno v: Journal of pharmacypharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 4(3)

The purpose of this project was to determine the effect of a FM-VP4 when incorporated into the diet or drinking water on plasma lipids, body weight, and hepatic and renal function following chronic oral administration to gerbils. Gerbils were adminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::452a043adbd3811f6e75d4b20dd5277a
https://pubmed.ncbi.nlm.nih.gov/11737988

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The effect of serum albumin on amphotericin B aggregate structure and activity

Autor: S C, Hartsel, E, Bauer, E H, Kwong, K M, Wasan

Publikováno v: Pharmaceutical research. 18(9)

Mild heat treatment of Fungizone (FZ, an amphotericin B:deoxycholate preparation) leads to a new self-associated form (HFZ) that demonstrates improved therapeutic index in vivo. The origin of the improvement may lie in the differential stability in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c8fa1e29081579ba64cf244c12cfb3
https://pubmed.ncbi.nlm.nih.gov/11683244

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Rat and rabbit plasma distribution of free and chylomicron-associated BIRT 377, a novel small molecule antagonist of LFA-1-mediated cell adhesion

Autor: K M, Wasan, M, Ramaswamy, L, Holtorf, A A, Jayaraj, D J, Hauss

Publikováno v: Pharmaceutical research. 18(4)

The objectives of this study are to determine the plasma distribution of free and chylomicron-associated BIRT 377 within rats and rabbits.For the rat studies free and chylomicron-associated BIRT 377 was incubated in plasma from CD 1 non-fasted rats f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c1d06c705ec77f7827953e4f2355d3d
https://pubmed.ncbi.nlm.nih.gov/11451039

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Heat-induced superaggregation of amphotericin B modifies its interaction with serum proteins and lipoproteins and stimulation of TNF-alpha

Autor: S C, Hartsel, B, Baas, E, Bauer, L T, Foree, K, Kindt, H, Preis, A, Scott, E H, Kwong, M, Ramaswamy, K M, Wasan

Publikováno v: Journal of pharmaceutical sciences. 90(2)

The purpose of the present study was to examine the influence of heat-induced superaggregation of Amphotericin B (AmB) in the Fungizone (FZ) formulation on its interaction with human serum components and relate this to reduced toxicity. Whole serum d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2cb247a5b9ebde29f8a415684bf4de2
https://pubmed.ncbi.nlm.nih.gov/11169529

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Assessing plasma pharmacokinetics of cholesterol following oral coadministration with a novel vegetable stanol mixture to fasting rats

Autor: K M, Wasan, L, Holtorf, R, Subramanian, S M, Cassidy, P H, Pritchard, D J, Stewart, E, Novak, M H, Moghadasian

Publikováno v: Journal of pharmaceutical sciences. 90(1)

The purpose of this project was to assess the plasma pharmacokinetics of [(3)H]cholesterol following coadministration of a novel vegetable stanol mixture composed of sitostanol and campestanol (FCP-3P4) to fasting rats. Following an overnight fast (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::137f75ba4901ad084257e5dd07e52cdb
https://pubmed.ncbi.nlm.nih.gov/11064375

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Cyclosporine transfer from low- and high-density lipoproteins is partially influenced by lipid transfer protein I triglyceride transfer activity

Autor: K M, Wasan, R, Subramanian, J W, Chou, M, Ramaswamy, P H, Pritchard

Publikováno v: Pharmaceutical research. 16(7)

The purpose of this study was to determine if lipid transfer protein (LTP I) facilitated triglyceride (TG) transfer activity regulates the plasma lipoprotein distribution of cyclosporine (CSA).To assess the influence of drug concentration and incubat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fde88959a6599b8cf1617f79775b869
https://pubmed.ncbi.nlm.nih.gov/10450932

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